Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 6/20 | 0.44 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8438436 | 0.95 | TBXAS1 (0.46) | SMN1; SMN2TBXAS1SUCNR1ALDH1A1CYP1A2 | |
| SCHEMBL8374897 | 0.95 | TBXAS1 (0.46) | SMN1; SMN2TBXAS1SUCNR1ALDH1A1CYP1A2 | |
| SCHEMBL8374491 | 0.82 | MEN1 (0.46) | SMN1; SMN2TBXAS1SUCNR1ALDH1A1CYP1A2 | |
| SCHEMBL8374493 | 0.82 | MEN1 (0.46) | SMN1; SMN2TBXAS1SUCNR1ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL10982425 | 0.76 | TBXAS1 (0.61) | TBXAS1ALDH1A1GAARECQL | |
| Hydrochloric Acid SCHEMBL10992507 | 0.76 | TBXAS1 (0.61) | TBXAS1ALDH1A1GAARECQL | |
| Hydrochloric Acid SCHEMBL8379790 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1CYP1A2HTR2AHTR2C | |
| SCHEMBL10987986 | 0.75 | TBXAS1 (0.59) | TBXAS1ALDH1A1GAARECQL | |
| SCHEMBL10987989 | 0.75 | TBXAS1 (0.59) | TBXAS1ALDH1A1GAARECQL | |
| SCHEMBL8831863 | 0.73 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1KDM4EMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883133-A | CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-16 | — | — | US | disclosed |