Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8374897 | 1.00 | TBXAS1 (0.46) | TBXAS1SMN1; SMN2ALDH1A1SUCNR1CYP1A2 | |
| Guanidine SCHEMBL8518148 | 0.95 | SMN1; SMN2 (0.46) | TBXAS1SMN1; SMN2ALDH1A1SUCNR1CYP1A2 | |
| SCHEMBL8374493 | 0.87 | MEN1 (0.46) | TBXAS1SMN1; SMN2ALDH1A1SUCNR1CYP1A2 | |
| SCHEMBL8374491 | 0.87 | MEN1 (0.46) | TBXAS1SMN1; SMN2ALDH1A1SUCNR1CYP1A2 | |
| SCHEMBL10987989 | 0.79 | TBXAS1 (0.59) | TBXAS1ALDH1A1AKR1C3GAARECQL | |
| SCHEMBL10987986 | 0.79 | TBXAS1 (0.59) | TBXAS1ALDH1A1AKR1C3GAARECQL | |
| Hydrochloric Acid SCHEMBL10992507 | 0.78 | TBXAS1 (0.61) | TBXAS1ALDH1A1AKR1C3GAARECQL | |
| Hydrochloric Acid SCHEMBL10982425 | 0.78 | TBXAS1 (0.61) | TBXAS1ALDH1A1AKR1C3GAARECQL | |
| SCHEMBL7995072 | 0.75 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1CYP1A2HTR2AHTR2C | |
| SCHEMBL14021961 | 0.75 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1SUCNR1CYP1A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755919-B1 | Substituted cinnamic acid guanidides, process for their preparation, their use as cardiovascualr medicament or diagnostic agent, as well as medicament containing them | HOECHST AG (DE) | 1999-11-17 | — | — | EP | claimed |