Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8375785 | 0.89 | MTNR1A (0.54) | RAB9ATP53SMN1; SMN2CYP1A2HPGD | |
| SCHEMBL8378941 | 0.88 | GABRA5 (0.46) | RAB9ASMN1; SMN2HIF1AFAAHMAPK1 | |
| SCHEMBL8375557 | 0.86 | BCHE (0.47) | FAAHHDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL8380154 | 0.85 | SMN1; SMN2 (0.55) | RAB9ATP53SMN1; SMN2CYP1A2HPGD | |
| Hydrochloric Acid SCHEMBL8378876 | 0.83 | CHRM4 (0.46) | RAB9ASMN1; SMN2NPC1ALDH1A1CHRM4 | |
| SCHEMBL8378917 | 0.81 | BCHE (0.49) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL8380141 | 0.78 | NPC1 (0.51) | RAB9ATP53SMN1; SMN2CYP1A2HPGD | |
| SCHEMBL8375005 | 0.78 | RAB9A (0.59) | RAB9ATP53SMN1; SMN2CYP1A2HPGD | |
| SCHEMBL8375021 | 0.78 | BCHE (0.57) | — | |
| SCHEMBL8375551 | 0.78 | HDAC1 (0.44) | RAB9ASMN1; SMN2NPC1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| CN-1216986-A | Isoxazole derivatives | SANKYO CO (JP) | 1999-05-19 | — | — | CN | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |