Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.55 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.53 |
| ▸ | LTA4H | P09960 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8375520 | 0.99 | CHRM1 (0.54) | CHRM1CHRM4CHRM5CHRM3HRH3 | |
| SCHEMBL8379062 | 0.99 | CHRM1 (0.56) | CHRM1CHRM4CHRM5CHRM3HRH3 | |
| Hydrochloric Acid SCHEMBL8380152 | 0.97 | CHRM1 (0.55) | CHRM1CHRM4CHRM5CHRM3HRH3 | |
| SCHEMBL8380069 | 0.88 | NPC1 (0.56) | HRH3CXCR1PTPN1LTA4HDRD1 | |
| Hydrochloric Acid SCHEMBL8380005 | 0.87 | NPC1 (0.59) | HRH3PTPN1LTA4H | |
| Hydrochloric Acid SCHEMBL8377507 | 0.86 | LTA4H (0.47) | CHRM1CHRM4CHRM5CHRM3CXCR1 | |
| SCHEMBL21121342 | 0.82 | CXCR1 (0.79) | HRH3CXCR1PTPN1LTA4H | |
| SCHEMBL21121935 | 0.82 | CXCR1 (0.79) | HRH3CXCR1PTPN1LTA4H | |
| SCHEMBL8376242 | 0.78 | SCD5 (0.52) | CHRM1CHRM4CHRM5CHRM3CXCR1 | |
| SCHEMBL5617855 | 0.76 | RAB9A (0.47) | CHRM1CHRM4CHRM5CHRM3CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |