Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8378946 | 0.98 | CXCR1 (0.40) | CXCR1CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL8378925 | 0.92 | CXCR1 (0.41) | CXCR1NPC1RAB9A | |
| SCHEMBL8375555 | 0.90 | NPC1 (0.35) | CXCR1NPC1RAB9ACASP3SENP8 | |
| SCHEMBL8379540 | 0.89 | ALDH1A1 (0.38) | CXCR1CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL8375770 | 0.89 | CXCR1 (0.43) | CXCR1NPC1RAB9ASMPD1 | |
| SCHEMBL8376906 | 0.89 | CXCR1 (0.40) | CXCR1NPC1RAB9APTGS2 | |
| SCHEMBL8378889 | 0.89 | CXCR1 (0.32) | CXCR1CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL8375023 | 0.89 | SMPD1 (0.47) | CXCR1SMPD1 | |
| SCHEMBL8380142 | 0.88 | HPGD (0.42) | CXCR1NPC1RAB9AALDH1A1 | |
| SCHEMBL8375816 | 0.88 | EPHX2 (0.38) | CXCR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |