Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | CDH1 | P12830 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8375555 | 0.90 | NPC1 (0.35) | CXCR1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL8374994 | 0.89 | THRB (0.38) | CXCR1MAPTHPGDSMPD1THRB | |
| SCHEMBL8375019 | 0.89 | NOTUM (0.41) | SMN1; SMN2NOTUMMAPTMEN1KMT2A | |
| SCHEMBL8376906 | 0.89 | CXCR1 (0.40) | CXCR1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL8375559 | 0.89 | CXCR1 (0.41) | CXCR1NPC1RAB9ASMPD1 | |
| SCHEMBL8379540 | 0.89 | ALDH1A1 (0.38) | CXCR1KDM4ETDP1NPC1RAB9A | |
| SCHEMBL8378889 | 0.89 | CXCR1 (0.32) | CXCR1SMPD1 | |
| SCHEMBL8378946 | 0.89 | CXCR1 (0.40) | CXCR1 | |
| SCHEMBL8380099 | 0.89 | TP53 (0.42) | CXCR1MAPTNPC1RAB9ATHRB | |
| SCHEMBL8380142 | 0.88 | HPGD (0.42) | CXCR1SMN1; SMN2MAPTKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |