SCHEMBL8375655

SCHEMBL8375655

N#CNC(=NCc1ccccc1)NN

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 4/20 0.54
NAMPT P43490 6/20 0.47
GRIN2B Q13224 6/20 0.46
GRIN1 Q05586 4/20 0.44
GRIN2D O15399 2/20 0.44
GRIN3B O60391 2/20 0.44
GRIN2A Q12879 2/20 0.44
GRIN2C Q14957 2/20 0.44
GRIN3A Q8TCU5 2/20 0.44
SIGMAR1 Q99720 2/20 0.44
NOS2 P35228 1/20 0.43
MAPKAPK2 P49137 1/20 0.41
CYP1A2 P05177 1/20 0.40
GAA P10253 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11743514 0.79 GRIN2B (0.59) P2RX7GRIN2BGRIN1GRIN2DGRIN3B
SCHEMBL9298550 0.76 NAMPT (0.61) P2RX7NAMPTMAPKAPK2
SCHEMBL9298551 0.76 NAMPT (0.61) P2RX7NAMPTMAPKAPK2
Iodide SCHEMBL11379056 0.76 NOS2 (0.50) GRIN2BGRIN1GRIN2DGRIN3BGRIN2A
Iodide SCHEMBL11379054 0.76 NOS2 (0.50) GRIN2BGRIN1GRIN2DGRIN3BGRIN2A
Iodide SCHEMBL11584597 0.75 GRIN2B (0.62) GRIN2BGRIN1GRIN2DGRIN3BGRIN2A
Iodide SCHEMBL11584596 0.75 GRIN2B (0.62) GRIN2BGRIN1GRIN2DGRIN3BGRIN2A
SCHEMBL4893130 0.73 P2RX7 (0.45) P2RX7NAMPTGRIN2BGRIN1GRIN2D
Iodide SCHEMBL11372887 0.73 GRIN2B (0.47) P2RX7GRIN2BGRIN1GRIN2DGRIN3B
Iodide SCHEMBL11372891 0.73 GRIN2B (0.47) P2RX7GRIN2BGRIN1GRIN2DGRIN3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0575490-B1 GnRH ANALOGS SALK INST FOR BIOLOGICAL STUDI (US) 1999-08-04 EP disclosed
EP-0703900-B1 PROCESS FOR THE PREPARATION OF PHENYLALANINE DERIVATIVES OR HOMOLOGUES CONTAINING A GUANIDINO OR MODIFIED GUANIDINO GROUP USEFUL FOR THE PREPARATION GnRH OF ANTAGONISTIC PEPTIDES SALK INST FOR BIOLOGICAL STUDI (US) 1999-02-24 EP disclosed
US-5744450-A DECAPEPTIDE HORMONE INHIBITOR THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1998-04-28 US disclosed
EP-0500695-B1 GnRH ANALOGS SALK INST FOR BIOLOGICAL STUDI (US) 1998-02-25 EP disclosed
US-5710249-A Amino acids and processes for making peptides using same THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1998-01-20 US disclosed
US-5580957-A GONADOTROPIN INHIBITOR THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1996-12-03 US disclosed
US-5565574-A BIOSYNTHESIS OF SYNTHETIC PEPTIDES THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1996-10-15 US disclosed
EP-0703900-A1 PROCESS FOR THE PREPARATION OF PHENYLALANINE DERIVATIVES OR HOMOLOGUES CONTAINING A GUANIDINO OR MODIFIED GUANIDINO GROUP USEFUL FOR THE PREPARATION GnRH OF ANTAGONISTIC PEPTIDES THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1996-04-03 EP disclosed
WO-1995000474-A1 PROCESS FOR THE PREPARATION OF PHENYLALANINE DERIVATIVES OR HOMOLOGUES CONTAINING A GUANIDINO OR MODIFIED GUANIDINO GROUP USEFUL FOR THE PREPARATION GnRH OF ANTAGONISTIC PEPTIDES THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1995-01-05 WO disclosed
US-5352796-A Chemical intermediates for gonadotropin-releasing hormone THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1994-10-04 US disclosed
US-5296468-A Antagonists of gonadotropin-releasing hormone; a decapeptide including an unnatural amino acid having a 3,5-diamino-1,2,4-triazole or a cyanoguanidine group; inhibits or promotes secretion of steroidal hormones; controls ovulation THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1994-03-22 US disclosed
EP-0575490-A1 GnRH ANALOGS THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1993-12-29 EP disclosed
EP-0500695-A4 GNRH ANALOGS 1993-06-09 EP disclosed
US-5169932-A Hormone inhibitors, antitumor agents THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1992-12-08 US disclosed
WO-1992017025-A2 GnRH ANALOGS THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1992-10-01 WO disclosed
EP-0500695-A1 GnRH ANALOGS THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1992-09-02 EP disclosed
WO-1991006543-A1 GnRH ANALOGS THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1991-05-16 WO disclosed