Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.45 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 6/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9315232 | 0.76 | GRIN1 (0.59) | NOS2GAACYP2C19GRIN2BGRIN1 | |
| SCHEMBL11743514 | 0.76 | GRIN2B (0.59) | P2RX7NOS2CYP1A2GAACYP2D6 | |
| SCHEMBL9315226 | 0.76 | GRIN1 (0.59) | NOS2GAACYP2C19GRIN2BGRIN1 | |
| SCHEMBL4891376 | 0.75 | P2RX7 (0.44) | P2RX7NOS2CYP1A2GAACYP2D6 | |
| SCHEMBL8375655 | 0.73 | P2RX7 (0.54) | P2RX7NOS2CYP1A2GAACYP2D6 | |
| SCHEMBL3968978 | 0.71 | KMT2A (0.54) | P2RX7NOS2CYP1A2GAACYP2D6 | |
| Hydrochloric Acid SCHEMBL16372137 | 0.69 | GRIN2B (0.61) | NOS2GRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL11800955 | 0.68 | GRIN1 (0.57) | NOS2GAACYP2C19GRIN2BGRIN1 | |
| SCHEMBL11800959 | 0.68 | GRIN1 (0.57) | NOS2GAACYP2C19GRIN2BGRIN1 | |
| SCHEMBL4893125 | 0.67 | MCL1 (0.46) | GAAGRIN2BGRIN1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312305-A1 | Imidazoles as Gaba- B Receptor Modulators | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | US | claimed |
| US-20080312305-A1 | Imidazoles as Gaba- B Receptor Modulators | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | US | disclosed |
| US-20080312305-A1 | Imidazoles as Gaba- B Receptor Modulators | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | US | disclosed |
| US-20080312305-A1 | Imidazoles as Gaba- B Receptor Modulators | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | US | disclosed |
| WO-2007073299-A1 | IMIDAZOLES AS GABA-B RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312305-A1 | Imidazoles as Gaba- B Receptor Modulators | GABRB1, GABBR2, GABRB2 | P2RX7 228/4885NOS2 1257/4885CYP1A2 701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.