Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28077720 | 0.94 | TSHR (0.57) | TSHRKMT2AALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL16050429 | 0.78 | TSHR (0.60) | TSHRKMT2AALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL28077872 | 0.78 | TSHR (0.64) | TSHRKMT2AALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL4097632 | 0.77 | PLK1 (0.46) | TSHRKMT2AMEN1 | |
| SCHEMBL14014030 | 0.77 | SMN1; SMN2 (0.50) | TSHRKMT2AALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL14257280 | 0.77 | SMN1; SMN2 (0.50) | TSHRKMT2AALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL4710089 | 0.77 | SMN1; SMN2 (0.53) | KMT2AALDH1A1NPSR1SMN1; SMN2KDM4E | |
| SCHEMBL27926754 | 0.75 | THRB (0.55) | TSHRKMT2AALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL5706065 | 0.75 | KMT2A (0.51) | TSHRKMT2AALDH1A1PTGS1PTGS2 | |
| SCHEMBL2097359 | 0.74 | KMT2A (0.55) | TSHRKMT2AALDH1A1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |