⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8379411 | 0.92 | GBA1 (0.30) | — | |
| Dimethylcarbate SCHEMBL8436988 | 0.86 | — | — | |
| Dimethylcarbate SCHEMBL8378396 | 0.69 | — | — | |
| Octane SCHEMBL4633409 | 0.62 | GPR84 (0.55) | — | |
| Nonane SCHEMBL9503204 | 0.62 | GPR84 (0.55) | — | |
| Decane SCHEMBL4634451 | 0.62 | GPR84 (0.55) | — | |
| Dodecane SCHEMBL8843443 | 0.62 | GPR84 (0.55) | — | |
| Hexane SCHEMBL6058673 | 0.60 | ALDH1A1 (0.55) | — | |
| SCHEMBL5361611 | 0.58 | GPR84 (0.44) | — | |
| SCHEMBL10878603 | 0.58 | GPR84 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869480-A | ALLEVIATING MEMORY DYSFUNCTION CHARACTERIZED BY CHOLINERGIC DEFICIT | HOECHST MARION ROUSSEL INC. (US) | 1999-02-09 | — | — | US | disclosed |
| US-5866565-A | ALZHEIMER'S DISORDERS | HOECHST MARION ROUSSEL INC. (US) | 1999-02-02 | — | — | US | disclosed |
| US-5821239-A | USEFUL FOR TREATING ALZHEIMER'S DISEASE CAUSED BY CHOLINERGIC DEFICIT | FROMMER LAWRENCE & HUAG LLP (US) | 1998-10-13 | — | — | US | disclosed |