SCHEMBL8377376

SCHEMBL8377376

CC(C)(C)OC(=O)NCCOc1cc(-c2ccccc2Cl)on1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 1/20 0.46
NPC1 O15118 6/20 0.45
HPGD P15428 4/20 0.45
ALDH1A1 P00352 4/20 0.45
CYP1A2 P05177 2/20 0.45
CYP2C19 P33261 2/20 0.45
CYP3A4 P08684 1/20 0.45
MAPT P10636 1/20 0.44
NPY1R P25929 1/20 0.44
NPY2R P49146 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CYP2C9 P11712 1/20 0.43
RAB9A P51151 5/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
MEN1 O00255 5/20 0.42
KMT2A Q03164 5/20 0.42
LMNA P02545 2/20 0.42
TSHR P16473 1/20 0.42
KDM4E B2RXH2 1/20 0.41
HSD17B10 Q99714 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8374999 0.92 PDK2 (0.44) PDK2NPC1HPGDALDH1A1CYP1A2
SCHEMBL8375687 0.89 IDO1 (0.49) PDK2NPC1HPGDALDH1A1CYP1A2
SCHEMBL8376833 0.88 LMNA (0.43) PDK2HPGDMEN1KMT2ALMNA
SCHEMBL8377366 0.88 PDK2 (0.46) PDK2NPC1HPGDALDH1A1CYP1A2
SCHEMBL8377397 0.87 HSD17B10 (0.58) PDK2NPC1HPGDALDH1A1MAPT
SCHEMBL8380157 0.86 PDK2 (0.48) PDK2NPC1HPGDALDH1A1CYP1A2
SCHEMBL8375694 0.86 NQO2 (0.44) PDK2HPGDALDH1A1CYP1A2CYP2C19
SCHEMBL8377508 0.85 PDK2 (0.41) PDK2HPGDALDH1A1CYP2C19MAPT
SCHEMBL8378941 0.85 GABRA5 (0.46) PDK2SMN1; SMN2RAB9AKMT2ACA12
SCHEMBL8375022 0.84 PDK2 (0.41) PDK2HPGDALDH1A1CYP2C19MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6005116-A HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA SANKYO COMPANY, LIMITED (JP) 1999-12-21 US disclosed
EP-0885891-A1 ISOXAZOLE DERIVATIVES SANKYO COMPANY LIMITED (JP) 1998-12-23 EP disclosed