Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 11/20 | 0.58 |
| ▸ | HPGD | P15428 | 9/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.58 |
| ▸ | RAB9A | P51151 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 9/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8377366 | 0.88 | PDK2 (0.46) | HSD17B10HPGDALDH1A1KDM4ERAB9A | |
| SCHEMBL8377376 | 0.87 | PDK2 (0.46) | HSD17B10HPGDALDH1A1KDM4ERAB9A | |
| SCHEMBL8375694 | 0.85 | NQO2 (0.44) | HSD17B10HPGDALDH1A1KDM4ERAB9A | |
| SCHEMBL8380157 | 0.85 | PDK2 (0.48) | HSD17B10HPGDALDH1A1KDM4ERAB9A | |
| SCHEMBL8378941 | 0.84 | GABRA5 (0.46) | RAB9ASMN1; SMN2KMT2APDK2 | |
| SCHEMBL8374999 | 0.83 | PDK2 (0.44) | HSD17B10HPGDALDH1A1KDM4ERAB9A | |
| SCHEMBL31725152 | 0.82 | HPGD (0.48) | HSD17B10HPGDALDH1A1KDM4ERAB9A | |
| SCHEMBL8375557 | 0.82 | BCHE (0.47) | PDK2 | |
| SCHEMBL8380153 | 0.82 | ACKR3 (0.44) | PDK2 | |
| SCHEMBL8380141 | 0.81 | NPC1 (0.51) | HSD17B10HPGDALDH1A1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |