Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221831 | 0.83 | ESR1 (0.46) | ADRA2AADRA2BTSHRADRA1AKCNH2 | |
| SCHEMBL8380076 | 0.81 | TDP2 (0.31) | SMN1; SMN2 | |
| SCHEMBL5610783 | 0.78 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CTSHRADRA1A | |
| SCHEMBL27391011 | 0.77 | TSHR (0.52) | ADRA2AADRA2BADRA2CTSHRADRA1A | |
| SCHEMBL18243012 | 0.76 | CA1 (0.40) | TSHRCYP1A2KCNH2CYP3A4CYP2D6 | |
| SCHEMBL8036242 | 0.76 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CTSHRADRA1A | |
| SCHEMBL375324 | 0.75 | LMNA (0.43) | ADRA2AADRA2BADRA2CTSHRADRA1A | |
| SCHEMBL16952697 | 0.75 | TSHR (0.39) | ADRA2AADRA2BADRA2CTSHRADRA1A | |
| SCHEMBL30271547 | 0.75 | LMNA (0.43) | ADRA2AADRA2BADRA2CTSHRADRA1A | |
| SCHEMBL5147323 | 0.75 | ADRA2A (0.39) | ADRA2AADRA2BADRA2CTSHRADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |