Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 4/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8517694 | 0.94 | CCR2 (0.41) | CCR2MCHR1HDAC1HDAC3HDAC4 | |
| SCHEMBL8375752 | 0.89 | POLB (0.39) | MCHR1MAPK1POLBMEN1KMT2A | |
| SCHEMBL8518008 | 0.87 | MEN1 (0.34) | CCR2MCHR1HDAC1HDAC3HDAC4 | |
| SCHEMBL8373964 | 0.86 | MCHR1 (0.38) | CCR2MCHR1ALDH1A1S1PR5 | |
| SCHEMBL8517601 | 0.85 | CCR3 (0.39) | MEN1KMT2A | |
| SCHEMBL8522255 | 0.84 | PLAAT3 (0.47) | POLBLMNAHRH3ALDH1A1 | |
| SCHEMBL20971523 | 0.84 | PLAAT3 (0.47) | POLBLMNAHRH3ALDH1A1 | |
| SCHEMBL20971533 | 0.84 | PLAAT3 (0.47) | POLBLMNAHRH3ALDH1A1 | |
| SCHEMBL8438262 | 0.84 | PLAAT3 (0.47) | POLBLMNAHRH3ALDH1A1 | |
| SCHEMBL8442091 | 0.84 | PLAAT3 (0.47) | POLBLMNAHRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900199-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-10 | — | — | EP | claimed |
| WO-1997041099-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-11-06 | — | — | WO | claimed |