Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7909446 | 0.91 | SMN1; SMN2 (0.49) | SMN1; SMN2PKMALDH1A1L3MBTL1POLB | |
| SCHEMBL7907917 | 0.90 | MEN1 (0.52) | SMN1; SMN2ALDH1A1POLBMAPTLMNA | |
| SCHEMBL8381940 | 0.89 | SMN1; SMN2 (0.52) | SMN1; SMN2PKMALDH1A1L3MBTL1POLB | |
| SCHEMBL8381010 | 0.87 | SMN1; SMN2 (0.55) | SMN1; SMN2PKMALDH1A1L3MBTL1POLB | |
| SCHEMBL8385319 | 0.86 | NAMPT (0.47) | L3MBTL1POLBKMT2AEPHX2 | |
| SCHEMBL8384343 | 0.85 | POLB (0.48) | SMN1; SMN2POLBMAPTLMNAKMT2A | |
| SCHEMBL7913458 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2PKMALDH1A1L3MBTL1POLB | |
| SCHEMBL8381170 | 0.83 | CHRM3 (0.49) | SMN1; SMN2ALDH1A1L3MBTL1POLBMAPT | |
| SCHEMBL7900164 | 0.82 | MEN1 (0.50) | SMN1; SMN2ALDH1A1POLBMAPTLMNA | |
| SCHEMBL8381648 | 0.80 | EPHX2 (0.49) | SMN1; SMN2ALDH1A1POLBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |