Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8380945 | 0.90 | SMN1; SMN2 (0.50) | KMT2AALDH1A1SMN1; SMN2POLBLMNA | |
| SCHEMBL7900164 | 0.90 | MEN1 (0.50) | MEN1KMT2AALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL8384256 | 0.89 | ALDH1A1 (0.51) | MEN1KMT2AALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL8381648 | 0.88 | EPHX2 (0.49) | MEN1KMT2AALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL8385319 | 0.88 | NAMPT (0.47) | MEN1KMT2APOLBCA1CA2 | |
| SCHEMBL8384343 | 0.87 | POLB (0.48) | MEN1KMT2ASMN1; SMN2POLBLMNA | |
| SCHEMBL7907929 | 0.87 | MEN1 (0.58) | MEN1KMT2AALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL7907920 | 0.85 | ITGB3 (0.53) | MEN1KMT2AALDH1A1TP53LMNA | |
| SCHEMBL7913440 | 0.83 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL7913420 | 0.82 | LMNA (0.49) | MEN1KMT2AALDH1A1SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |