Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900164 | 0.91 | MEN1 (0.50) | SMN1; SMN2EPHX2GAAALDH1A1ITGB3 | |
| SCHEMBL8380945 | 0.91 | SMN1; SMN2 (0.50) | SMN1; SMN2EPHX2PKML3MBTL1ALDH1A1 | |
| SCHEMBL7913458 | 0.90 | SMN1; SMN2 (0.52) | SMN1; SMN2EPHX2GAAPKML3MBTL1 | |
| SCHEMBL7909721 | 0.87 | POLB (0.46) | EPHX2GAAITGB3ITGA2BPOLB | |
| SCHEMBL8381010 | 0.87 | SMN1; SMN2 (0.55) | SMN1; SMN2PKML3MBTL1ALDH1A1POLB | |
| SCHEMBL7907928 | 0.86 | GAA (0.45) | SMN1; SMN2EPHX2GAAL3MBTL1ITGB3 | |
| SCHEMBL8381648 | 0.85 | EPHX2 (0.49) | SMN1; SMN2EPHX2GAAALDH1A1ITGB3 | |
| SCHEMBL8381940 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2PKML3MBTL1ALDH1A1POLB | |
| SCHEMBL9335780 | 0.85 | ITGB3 (0.50) | SMN1; SMN2GAAALDH1A1ITGB3ITGA2B | |
| SCHEMBL7909440 | 0.84 | ITGB3 (0.54) | SMN1; SMN2EPHX2GAAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |