Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA6 | P23280 | 2/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL20984925 | 0.97 | EGFR (0.37) | EGFRIDO1LMNACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL20984617 | 0.97 | EGFR (0.37) | EGFRIDO1LMNACYP1A2CYP3A4 | |
| Sulfuric Acid SCHEMBL20984228 | 0.86 | CA2 (0.40) | EGFRLMNACYP3A4TDP1ALDH1A1 | |
| Oxalic Acid SCHEMBL20984598 | 0.86 | MEN1 (0.36) | EGFRLMNAALDH1A1 | |
| Phosphoric Acid SCHEMBL20984457 | 0.86 | ALDH1A1 (0.34) | EGFRLMNAALDH1A1CA1CA2 | |
| Nitric Acid SCHEMBL20984346 | 0.84 | ALDH1A1 (0.35) | EGFRLMNACYP2D6TDP1ALDH1A1 | |
| SCHEMBL850140 | 0.83 | GAA (0.42) | EGFRLMNACYP1A2TDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3712543 | 0.81 | HTT (0.35) | EGFRIDO1LMNAALDH1A1CA1 | |
| Hydrochloric Acid SCHEMBL838769 | 0.81 | GAA (0.41) | EGFRIDO1LMNACYP1A2TDP1 | |
| SCHEMBL27976592 | 0.76 | PRNP (0.46) | ALDH1A1CA1CA2CA6CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112409203-B | Method for simultaneously synthesizing phenylhydrazine salt and pyruvic acid or glyoxylic acid | 帕潘纳(北京)科技有限公司 | 2022-10-25 | — | — | CN | disclosed |
| CN-112409203-A | Method for simultaneously synthesizing phenylhydrazine salt and pyruvic acid or glyoxylic acid | 帕潘纳(北京)科技有限公司 | 2021-02-26 | — | — | CN | disclosed |
| CN-104974161-B | The analog of 4H- pyrazolo [1,5- α] benzimidazole compound as PARP inhibitor | Hubei company limited of Bio-pharmaceutical Industry Institute for Research and Technology (CN) | 2019-11-01 | — | — | CN | disclosed |
| EP-3130592-B1 | ANALOGUES OF 4H-PYRAZOLO[1,5- ]BENZIMIDAZOLE COMPOUND AS PARP INHIBITORS | HUBEI BIO PHARMACEUTICAL INDUSTRIAL TECH INSTITUTE INC (CN) | 2019-08-14 | — | — | EP | disclosed |
| CN-106459057-B | Analogs of 4H-pyrazolo [1,5- α ] benzimidazole compounds as PARP inhibitors | 湖北生物医药产业技术研究院有限公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-107663161-A | A kind of continuous stream synthesis technique of phenylhydrazine salt and substituted benzene hydrazonium salt | 上海惠和化德生物科技有限公司 | 2018-02-06 | — | — | CN | disclosed |
| US-9856262-B2 | Analogues of 4H-pyrazolo[1,5-a] benzimidazole compound as PARP inhibitors | HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE INC. (CN) | 2018-01-02 | — | — | US | disclosed |
| EP-3130592-A1 | ANALOGUES OF 4H-PYRAZOLO[1,5- ]BENZIMIDAZOLE COMPOUND AS PARP INHIBITORS | Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. (CN) | 2017-02-15 | — | — | EP | disclosed |
| US-20170029430-A1 | ANALOGUES OF 4H-PYRAZOLO[1,5-a] BENZIMIDAZOLE COMPOUND AS PARP INHIBITORS | HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE INC. (CN) | 2017-02-02 | — | — | US | disclosed |
| US-8143263-B2 | Therapeutic agents | ASTRAZENECA AB (SE) | 2012-03-27 | — | — | US | disclosed |
| EP-2324028-A2 | THERAPEUTIC AGENTS 414 | AstraZeneca AB (SE) | 2011-05-25 | — | — | EP | disclosed |
| US-20100093757-A1 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-04-15 | — | — | US | disclosed |
| WO-2010015849-A2 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170029430-A1 | ANALOGUES OF 4H-PYRAZOLO[1,5-a] BENZIMIDAZOLE COMPOUND AS PARP INHIBITORS | PARP1, PARP2, PARP11 | EGFR 3551/4885IDO1 1536/4885LMNA 923/4885 |
| US-20100093757-A1 | THERAPEUTIC AGENTS 414 | GCK, GCKR, GPR119 | EGFR 3951/4885IDO1 3277/4885LMNA 3530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.