SCHEMBL838429

SCHEMBL838429

Cc1cc(Nc2ccc(Br)cc2)nc2ccccc12

nearest known ligand 0.70

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.70
MEN1 O00255 6/20 0.70
MAPT P10636 6/20 0.70
SMN1; SMN2 Q16637 4/20 0.70
LMNA P02545 4/20 0.70
KDM4E B2RXH2 4/20 0.70
RAB9A P51151 3/20 0.70
POLB P06746 1/20 0.59
F2 P00734 1/20 0.57
ALDH1A1 P00352 1/20 0.52
HPGD P15428 1/20 0.52
NPC1 O15118 2/20 0.51
GAA P10253 1/20 0.50
HTT P42858 1/20 0.50
ABCG2 Q9UNQ0 1/20 0.50
SLC2A1 P11166 1/20 0.49
CYP1A2 P05177 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30917200 1.00 KMT2A (0.70) KMT2AMEN1MAPTSMN1; SMN2LMNA
SCHEMBL837692 0.89 MEN1 (0.75) KMT2AMEN1MAPTSMN1; SMN2LMNA
SCHEMBL837706 0.88 MEN1 (0.74) KMT2AMEN1MAPTSMN1; SMN2LMNA
SCHEMBL4817753 0.85 KDM4E (0.70) KMT2AMEN1MAPTSMN1; SMN2LMNA
SCHEMBL837756 0.82 RAB9A (0.70) KMT2AMEN1MAPTSMN1; SMN2LMNA
SCHEMBL14420787 0.81 MEN1 (0.65) KMT2AMEN1MAPTSMN1; SMN2LMNA
SCHEMBL1702071 0.78 MEN1 (0.72) KMT2AMEN1MAPTSMN1; SMN2LMNA
SCHEMBL838095 0.77 MAPT (0.71) KMT2AMEN1MAPTSMN1; SMN2LMNA
Hydrochloric Acid SCHEMBL13518268 0.77 MEN1 (0.70) KMT2AMEN1MAPTSMN1; SMN2LMNA
SCHEMBL11712509 0.77 KDM4E (0.65) KMT2AMEN1MAPTSMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11298348-B2 Combination treatment of sarcoglycanopathies INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MÉDICALE) (FR) 2022-04-12 US claimed
US-20210059999-A1 COMBINATION TREATMENT OF SARCOGLYCANOPATHIES UNIVERSITE D'EVRY-VAL-D'ESSONNE (FR) 2021-03-04 US claimed
CN-112203654-A Combination therapy for sarcoglycemia 国家健康与医学研究院 2021-01-08 CN claimed
EP-3737375-A1 COMBINATION TREATMENT OF SARCOGLYCANOPATHIES INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2020-11-18 EP claimed
EP-2925317-B1 A CFTR CORRECTOR FOR THE TEATMENT OF GENETIC DISORDERS AFFECTING STRIATED MUSCLE UNIV DEGLI STUDI PADOVA (IT) 2019-09-04 EP claimed
US-20180221347-A1 CFTR CORRECTOR FOR THE TREATMENT OF GENETIC DISORDERS AFFECTING STRIATED MUSCLE UNIVERSITA' DEGLI STUDI DI PADOVA (IT) 2018-08-09 US claimed
US-9987256-B2 CFTR corrector for the treatment of genetic disorders affecting striated muscle UNIVERSITA' DEGLI STUDI DI PADOVA (IT) 2018-06-05 US claimed
US-20160108406-A1 METHOD OF REGULATING CFTR EXPRESSION AND PROCESSING UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2016-04-21 US claimed
US-20150328217-A1 A CFTR CORRECTOR FOR THE TREATMENT OF GENETIC DISORDERS AFFECTING STRIATED MUSCLE UNIVERSITA' DEGLI STUDI DI PADOVA (IT) 2015-11-19 US claimed
EP-2925317-A1 A CFTR CORRECTOR FOR THE TEATMENT OF GENETIC DISORDERS AFFECTING STRIATED MUSCLE Università Degli Studi Di Padova (IT) 2015-10-07 EP claimed
WO-2014086687-A1 A CFTR CORRECTOR FOR THE TEATMENT OF GENETIC DISORDERS AFFECTING STRIATED MUSCLE UNIVERSITA' DEGLI STUDI DI PADOVA (IT) 2014-06-12 WO claimed
US-11988661-B2 Rapid quantitative test to diagnose polycystic kidney disease UMC UTRECHT HOLDING, B.V. (NL) 2024-05-21 US disclosed
US-11298348-B2 Combination treatment of sarcoglycanopathies INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MÉDICALE) (FR) 2022-04-12 US disclosed
US-20210333266-A1 RAPID QUANTITATIVE ASSAY TO MEASURE CFTR FUNCTION IN A PRIMARY INTESTINAL CULTURE MODEL UMC UTRECHT HOLDING, B.V. (NL) 2021-10-28 US disclosed
US-20210333266-A1 RAPID QUANTITATIVE ASSAY TO MEASURE CFTR FUNCTION IN A PRIMARY INTESTINAL CULTURE MODEL UMC UTRECHT HOLDING, B.V. (NL) 2021-10-28 US disclosed
US-8143295-B2 Compounds having activity in correcting mutant-CFTR processing and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-03-27 US disclosed
US-8143295-B2 Compounds having activity in correcting mutant-CFTR processing and uses thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-03-27 US disclosed
WO-2009105234-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH DEFECTS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR GENE OR PROTEIN COMBINATORX, INCORPORATED (US) 2009-08-27 WO disclosed
US-20080318984-A1 Compounds Having Activity in Correcting Mutant-Cftr Processing and Uses Thereof NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2008-12-25 US disclosed
US-20080318984-A1 Compounds Having Activity in Correcting Mutant-Cftr Processing and Uses Thereof NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2008-12-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180221347-A1 CFTR CORRECTOR FOR THE TREATMENT OF GENETIC DISORDERS AFFECTING STRIATED MUSCLE CFTR, CLCN2, ATP4A KMT2A 3813/4885MEN1 3957/4885MAPT 3636/4885
US-20150328217-A1 A CFTR CORRECTOR FOR THE TREATMENT OF GENETIC DISORDERS AFFECTING STRIATED MUSCLE CFTR, CLCN2, ATP4A KMT2A 3932/4885MEN1 4212/4885MAPT 3980/4885
US-20160108406-A1 METHOD OF REGULATING CFTR EXPRESSION AND PROCESSING CFTR, NEDD8, SCNN1B KMT2A 2228/4885MEN1 2750/4885MAPT 4644/4885
US-20080318984-A1 Compounds Having Activity in Correcting Mutant-Cftr Processing and Uses Thereof CFTR, ABCC5, QPCT KMT2A 4258/4885MEN1 4634/4885MAPT 4358/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.