Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.38 |
| ▸ | SLC2A2 | P11168 | 3/20 | 0.38 |
| ▸ | SLC2A3 | P11169 | 3/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL849766 | 0.86 | MAPT (0.46) | RAB9ANPC1KDM4EHSD17B10HTT | |
| SCHEMBL838405 | 0.84 | TP53 (0.44) | RAB9ANPC1KDM4EHSD17B10HTT | |
| SCHEMBL839927 | 0.84 | SLC2A1 (0.44) | RAB9ANPC1KDM4EHSD17B10HTT | |
| SCHEMBL838736 | 0.82 | ALDH1A1 (0.40) | RAB9ANPC1KDM4EHSD17B10HTT | |
| SCHEMBL839132 | 0.81 | SLC2A1 (0.47) | RAB9ANPC1KDM4EHSD17B10HTT | |
| SCHEMBL839998 | 0.76 | TP53 (0.47) | RAB9ANPC1KDM4EHTTTP53 | |
| SCHEMBL838719 | 0.76 | MAPK14 (0.42) | RAB9ANPC1KDM4EHSD17B10HTT | |
| SCHEMBL838812 | 0.76 | P2RX7 (0.44) | RAB9ANPC1KDM4EHSD17B10HTT | |
| SCHEMBL878705 | 0.75 | GCK (0.47) | RAB9AKDM4EHSD17B10MAPTSLC2A1 | |
| SCHEMBL12000897 | 0.75 | SLC2A1 (0.53) | KDM4EHSD17B10TP53MAPTSLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143263-B2 | Therapeutic agents | ASTRAZENECA AB (SE) | 2012-03-27 | — | — | US | disclosed |
| EP-2324028-A2 | THERAPEUTIC AGENTS 414 | AstraZeneca AB (SE) | 2011-05-25 | — | — | EP | disclosed |
| US-20100093757-A1 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-04-15 | — | — | US | disclosed |
| WO-2010015849-A2 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093757-A1 | THERAPEUTIC AGENTS 414 | GCK, GCKR, GPR119 | RAB9A 3239/4885NPC1 552/4885KDM4E 3541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.