SCHEMBL8384648

SCHEMBL8384648

CC(CC#N)C(Br)(Br)C#N.CC(O)Oc1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.36
PBRM1 Q86U86 1/20 0.35
CTSS P25774 5/20 0.34
CTSL P07711 3/20 0.34
MTNR1A P48039 1/20 0.33
MTNR1B P49286 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
TDP1 Q9NUW8 1/20 0.32
CTSB P07858 1/20 0.31
CTSK P43235 1/20 0.31
GHSR Q92847 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8895999 0.83 PBRM1 (0.35) LMNAPBRM1CTSSCTSLCYP3A4
Phenoxyethanol SCHEMBL5691829 0.81 ALDH1A1 (0.51) LMNACYP3A4TDP1
SCHEMBL8895995 0.80 PBRM1 (0.33) LMNAPBRM1CTSSCTSLCYP3A4
SCHEMBL7764504 0.77 LMNA (0.43) LMNAMTNR1AMTNR1BCYP2D6GHSR
Water SCHEMBL30489926 0.76 LMNA (0.50) LMNAMTNR1AMTNR1BCYP2D6
Water SCHEMBL28244606 0.76 LMNA (0.50) LMNAMTNR1AMTNR1BCYP2D6
SCHEMBL223764 0.76 TSHR (0.32)
SCHEMBL5484514 0.74 TSHR (0.31)
SCHEMBL167127 0.74 LMNA (0.52) LMNAMTNR1AMTNR1BCYP2D6
SCHEMBL15709 0.74 LMNA (0.52) LMNAMTNR1AMTNR1BCYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2699219-B1 SELF-TANNING COMPOSITIONS HAVING REDUCED MAILLARD REACTION MALODOR KAO USA INC (US) 2019-10-23 EP disclosed
US-20170290758-A1 Optimized Skincare Regimens for Changing the Genetic Skin Type to the Ideal Skin Type - Oily, Resistant, Non-Pigmented and Tight Skin METABEAUTY, INC. 2017-10-12 US disclosed
US-9724287-B2 Optimized skincare regimens for changing the genetic skin type to the ideal skin type—oily, resistant, non-pigmented and tight skin METABEAUTY, INC. (US) 2017-08-08 US disclosed
US-9452125-B2 Self-tanning compositions having reduced maillard reaction malodor KAO USA INC. (US) 2016-09-27 US disclosed
US-20160128925-A1 Optimized Skincare Regimens for Changing the Genetic Skin Type to the Ideal Skin Type - Oily, Resistant, Non-Pigmented and Tight Skin METABEAUTY, INC. 2016-05-12 US disclosed
EP-2699219-A2 SELF-TANNING COMPOSITIONS HAVING REDUCED MAILLARD REACTION MALODOR Kao Corporation (JP) 2014-02-26 EP disclosed
WO-2012145638-A2 SELF-TANNING COMPOSITIONS HAVING REDUCED MAILLARD REACTION MALODOR KAO CORPORATION (JP) 2012-10-26 WO disclosed
US-20120269743-A1 SELF-TANNING COMPOSITIONS HAVING REDUCED MAILLARD REACTION MALODOR KAO USA INC. (US) 2012-10-25 US disclosed
EP-0907355-A1 SKIN WASH COMPOSITIONS COMPRISING TRICLOCARBAN AND SURFACTANTS SMITHKLINE BEECHAM PLC (GB) 1999-04-14 EP disclosed
WO-1997048377-A1 SKIN WASH COMPOSITIONS COMPRISING TRICLOCARBAN AND SURFACTANTS SMITHKLINE BEECHAM PLC (GB) 1997-12-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160128925-A1 Optimized Skincare Regimens for Changing the Genetic Skin Type to the Ideal Skin Type - Oily, Resistant, Non-Pigmented and Tight Skin CUTA, UBQLN2, BRCA1 LMNA 643/4885PBRM1 2149/4885CTSS 4804/4885
US-20170290758-A1 Optimized Skincare Regimens for Changing the Genetic Skin Type to the Ideal Skin Type - Oily, Resistant, Non-Pigmented and Tight Skin CUTA, UBQLN2, BRCA1 LMNA 643/4885PBRM1 2149/4885CTSS 4804/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.