Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 14/20 | 0.58 |
| ▸ | PPARD | Q03181 | 1/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | GNA15 | P30679 | 1/20 | 0.45 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8383450 | 0.86 | PLA2G4B (0.51) | FFAR1PPARD | |
| SCHEMBL8385078 | 0.85 | FFAR1 (0.68) | FFAR1PPARDFFAR4AKR1B1 | |
| SCHEMBL8381123 | 0.85 | CYSLTR2 (0.52) | FFAR1FFAR4 | |
| SCHEMBL17413767 | 0.83 | FFAR1 (0.71) | FFAR1PPARDFFAR4KEAP1AKR1B1 | |
| SCHEMBL8385021 | 0.82 | TAAR1 (0.50) | KCNH2 | |
| SCHEMBL17413763 | 0.82 | FFAR1 (0.69) | FFAR1PPARDFFAR4AKR1B1 | |
| SCHEMBL25175611 | 0.81 | FFAR1 (0.76) | FFAR1FFAR4KEAP1 | |
| SCHEMBL8383409 | 0.81 | LMNA (0.56) | FFAR1PPARD | |
| SCHEMBL1206748 | 0.79 | LMNA (0.68) | FFAR1PPARDFFAR4 | |
| SCHEMBL2772855 | 0.79 | FFAR1 (0.83) | FFAR1FFAR4AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874436-A | EFFECTIVE IN INHIBITING THE ACTION OF A BACTERIAL HISTIDINE PROTEIN KINASE; USEFUL AGAINST ANTIBIOTIC RESISTANT ORGANISMS | DEMERS JAMES P (US) | 1999-02-23 | — | — | US | disclosed |
| US-5643950-A | INHIBITORS OF A BACTERIAL HISTIDINE PROTEIN KINASE | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-07-01 | — | — | US | disclosed |