Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | CD69 | Q07108 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8381329 | 0.89 | ALOX15 (0.59) | ALOX15PLA2G4BPTPN7PPARGALDH1A1 | |
| SCHEMBL8381123 | 0.87 | CYSLTR2 (0.52) | DHFRPPARAFFAR1 | |
| SCHEMBL8385089 | 0.86 | KMT2A (0.50) | LMNAKDM4EALDH1A1 | |
| SCHEMBL8383450 | 0.83 | PLA2G4B (0.51) | LMNAPLA2G4BKDM4EALDH1A1FFAR1 | |
| SCHEMBL8383452 | 0.83 | LMNA (0.46) | LMNAMAPK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8385013 | 0.81 | FFAR1 (0.58) | FFAR1PPARD | |
| SCHEMBL8385016 | 0.81 | ACHE (0.48) | LMNAMAPK1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL413254 | 0.80 | LMNA (0.81) | LMNAALOX15PLA2G4BPTPN7MAPK1 | |
| SCHEMBL8385001 | 0.80 | L3MBTL1 (0.56) | LMNAALOX15PTGDR2KDM4EALDH1A1 | |
| SCHEMBL8379807 | 0.80 | DRD4 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874436-A | EFFECTIVE IN INHIBITING THE ACTION OF A BACTERIAL HISTIDINE PROTEIN KINASE; USEFUL AGAINST ANTIBIOTIC RESISTANT ORGANISMS | DEMERS JAMES P (US) | 1999-02-23 | — | — | US | disclosed |
| US-5643950-A | INHIBITORS OF A BACTERIAL HISTIDINE PROTEIN KINASE | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-07-01 | — | — | US | disclosed |