Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 16/20 | 0.68 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.56 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARD | Q03181 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8385027 | 0.92 | FFAR1 (0.63) | FFAR1FFAR4LMNAL3MBTL1ITGB3 | |
| SCHEMBL8384111 | 0.87 | PPARA (0.55) | FFAR1FFAR4PPARGPPARA | |
| SCHEMBL8385005 | 0.85 | LTB4R (0.49) | FFAR1LMNAAKR1B1PPARD | |
| SCHEMBL8385013 | 0.85 | FFAR1 (0.58) | FFAR1FFAR4AKR1B1PPARD | |
| SCHEMBL8383194 | 0.82 | TAAR1 (0.52) | FFAR1LMNA | |
| SCHEMBL8381329 | 0.82 | ALOX15 (0.59) | FFAR1FFAR4PPARGPPARD | |
| SCHEMBL1745370 | 0.82 | FFAR1 (1.00) | FFAR1FFAR4LMNAL3MBTL1AKR1B1 | |
| SCHEMBL4530820 | 0.82 | FFAR1 (0.88) | FFAR1FFAR4LMNAL3MBTL1S1PR1 | |
| SCHEMBL24724221 | 0.81 | L3MBTL1 (0.69) | FFAR1FFAR4LMNAL3MBTL1ITGB3 | |
| SCHEMBL8381114 | 0.81 | LTA4H (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874436-A | EFFECTIVE IN INHIBITING THE ACTION OF A BACTERIAL HISTIDINE PROTEIN KINASE; USEFUL AGAINST ANTIBIOTIC RESISTANT ORGANISMS | DEMERS JAMES P (US) | 1999-02-23 | — | — | US | disclosed |
| US-5643950-A | INHIBITORS OF A BACTERIAL HISTIDINE PROTEIN KINASE | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-07-01 | — | — | US | disclosed |