Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 14/20 | 0.45 |
| ▸ | HTR1D | P28221 | 9/20 | 0.45 |
| ▸ | HTR1B | P28222 | 8/20 | 0.45 |
| ▸ | HTR1A | P08908 | 8/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR1E | P28566 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8383659 | 0.87 | MAPT (0.43) | HTR1FHTR1DHTR1BHTR1ANPC1 | |
| SCHEMBL8385333 | 0.84 | HTR1F (0.40) | HTR1FHTR1DHTR1BHTR1ANPC1 | |
| SCHEMBL8724084 | 0.83 | HTR1F (0.60) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL8381812 | 0.82 | HTR1F (0.63) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL8385510 | 0.80 | HTR1F (0.59) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL8385395 | 0.80 | HTR1F (0.53) | HTR1FHTR1DHTR1BHTR1ANPC1 | |
| SCHEMBL8385462 | 0.79 | HTR1F (0.62) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| Fumaric Acid SCHEMBL8386515 | 0.78 | HTR1F (0.59) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL8382171 | 0.78 | NOS3 (0.44) | HTR1DHTR1BMAPT | |
| SCHEMBL8386631 | 0.78 | HTR1F (0.56) | HTR1FHTR1DHTR1BHTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874427-A | MIGRAINE | ELI LILLY AND COMPANY (US) | 1999-02-23 | — | — | US | disclosed |
| EP-0875513-A1 | Substituted heteroaromatic 5-HT 1F agonists | ELI LILLY AND COMPANY (US) | 1998-11-04 | — | — | EP | disclosed |