Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 12/20 | 0.40 |
| ▸ | HTR1D | P28221 | 8/20 | 0.39 |
| ▸ | HTR1B | P28222 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8385402 | 0.87 | MAPT (0.41) | HTR1DHTR1BMAPTLMNAMEN1 | |
| SCHEMBL8385487 | 0.84 | HTR1F (0.45) | HTR1FHTR1DHTR1BMAPTSMN1; SMN2 | |
| SCHEMBL8385510 | 0.81 | HTR1F (0.59) | HTR1FHTR1DHTR1BHTR1APARP1 | |
| SCHEMBL8385395 | 0.80 | HTR1F (0.53) | HTR1FHTR1DHTR1BNPC1HTR1A | |
| SCHEMBL8386633 | 0.80 | NOS3 (0.41) | HTR1DHTR1BMAPTLMNAMEN1 | |
| SCHEMBL8724084 | 0.79 | HTR1F (0.60) | HTR1FHTR1DHTR1BHTR1A | |
| SCHEMBL8385462 | 0.77 | HTR1F (0.62) | HTR1FHTR1DHTR1BHTR1A | |
| SCHEMBL8725966 | 0.77 | HTR1F (0.46) | HTR1FHTR1DHTR1BMAPTHTR1A | |
| SCHEMBL8384351 | 0.75 | HTR1F (0.41) | HTR1FHTR1DHTR1BKMT2AHTR1A | |
| SCHEMBL8386478 | 0.75 | HTR1F (0.48) | HTR1FHTR1DHTR1BHTR1APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874427-A | MIGRAINE | ELI LILLY AND COMPANY (US) | 1999-02-23 | — | — | US | disclosed |
| EP-0875513-A1 | Substituted heteroaromatic 5-HT 1F agonists | ELI LILLY AND COMPANY (US) | 1998-11-04 | — | — | EP | disclosed |