Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | CCNC | P24863 | 2/20 | 0.49 |
| ▸ | CDK8 | P49336 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8382617 | 0.91 | NAMPT (0.49) | POLBCCNCCDK8CHRM3NAMPT | |
| SCHEMBL7909845 | 0.88 | ITGB3 (0.56) | POLBCCNCCDK8NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7909753 | 0.87 | POLB (0.57) | POLBCCNCCDK8NPC1RAB9A | |
| SCHEMBL8386242 | 0.86 | EPHX2 (0.54) | POLBCCNCCDK8NPC1RAB9A | |
| SCHEMBL8384343 | 0.84 | POLB (0.48) | POLBNPC1RAB9ANAMPTUSP2 | |
| SCHEMBL8381170 | 0.82 | CHRM3 (0.49) | POLBCHRM3CYP2C19ALDH1A1MAPT | |
| SCHEMBL7900157 | 0.82 | ITGB3 (0.51) | POLBCCNCCDK8CHRM3NAMPT | |
| SCHEMBL8381985 | 0.79 | HTT (0.45) | POLBCCNCCDK8CHRM3NAMPT | |
| SCHEMBL8386146 | 0.79 | POLB (0.51) | POLBCCNCCDK8NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7909852 | 0.78 | POLB (0.51) | POLBCCNCCDK8NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |