Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 6/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.51 |
| ▸ | ITGA2 | P17301 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | CCNC | P24863 | 2/20 | 0.44 |
| ▸ | CDK8 | P49336 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8382617 | 0.91 | NAMPT (0.49) | POLBNAMPTCCNCCDK8EPHX2 | |
| SCHEMBL7909845 | 0.91 | ITGB3 (0.56) | ITGB3ITGA2BITGA2GAAPOLB | |
| Hydrochloric Acid SCHEMBL7909753 | 0.89 | POLB (0.57) | ITGB3ITGA2BITGA2GAAPOLB | |
| SCHEMBL7907928 | 0.86 | GAA (0.45) | ITGB3ITGA2BITGA2GAANAMPT | |
| SCHEMBL8386146 | 0.86 | POLB (0.51) | POLBCCNCCDK8EPHX2HTT | |
| SCHEMBL8386242 | 0.84 | EPHX2 (0.54) | ITGB3ITGA2BITGA2POLBNAMPT | |
| SCHEMBL7909438 | 0.84 | ITGB3 (0.54) | ITGB3ITGA2BITGA2GAAPOLB | |
| SCHEMBL8381985 | 0.84 | HTT (0.45) | POLBNAMPTCCNCCDK8CHRM3 | |
| SCHEMBL7909440 | 0.83 | ITGB3 (0.54) | ITGB3ITGA2BITGA2GAAPOLB | |
| SCHEMBL8385665 | 0.82 | POLB (0.58) | POLBNAMPTCCNCCDK8EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |