Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 8/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8488639 | 0.79 | AHR (0.43) | NFE2L2PTGS1ALOX5PTGS2FBP1 | |
| SCHEMBL12495291 | 0.79 | PTGS1 (0.42) | NFE2L2NQO2PTGS1PTGS2 | |
| SCHEMBL770392 | 0.78 | MAOB (0.44) | NFE2L2TRPA1 | |
| SCHEMBL8491011 | 0.77 | NPC1 (0.48) | NFE2L2ALOX5 | |
| SCHEMBL9718330 | 0.76 | NFE2L2 (0.59) | NFE2L2TRPA1NQO2PTGS1APP | |
| SCHEMBL10567248 | 0.75 | NFE2L2 (0.54) | NFE2L2NQO2PTGS1APPHSD11B1 | |
| SCHEMBL8462151 | 0.73 | XDH (0.47) | APPFBP1 | |
| SCHEMBL22468800 | 0.71 | NFE2L2 (0.78) | NFE2L2NQO2PTGS1APPHSD11B1 | |
| SCHEMBL700051 | 0.71 | NFE2L2 (0.78) | NFE2L2NQO2PTGS1APPHSD11B1 | |
| SCHEMBL13766470 | 0.71 | NFE2L2 (0.78) | NFE2L2NQO2PTGS1APPHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4165023-A1 | INHIBITORS OF APOL1 AND USE OF THE SAME | Vertex Pharmaceuticals Incorporated (US) | 2023-04-19 | — | — | EP | disclosed |
| CN-115867532-A | Inhibitors of APOL1 and uses thereof | 弗特克斯药品有限公司 | 2023-03-28 | — | — | CN | disclosed |
| EP-0743938-B1 | SUBSTITUTED SPIRO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 1999-04-21 | — | — | EP | disclosed |