SCHEMBL8386604

SCHEMBL8386604

CCCc1cccc(C(=O)c2ccc3[nH]cc(C4CCN5CCCC5C4)c3c2)c1

nearest known ligand 0.46

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 7/20 0.46
HTR1D P28221 8/20 0.41
HTR1B P28222 8/20 0.41
HTR1A P08908 3/20 0.39
NOS1 P29475 1/20 0.38
OPRM1 P35372 1/20 0.38
OPRK1 P41145 1/20 0.38
OPRL1 P41146 1/20 0.38
MTNR1A P48039 1/20 0.38
MTNR1B P49286 1/20 0.38
HTR1F P30939 2/20 0.38
HSD11B1 P28845 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30908881 1.00 SLC6A4 (0.46) SLC6A4HTR1DHTR1BHTR1ANOS1
SCHEMBL8386447 0.86 SLC6A4 (0.49) SLC6A4HTR1DHTR1BHTR1ANOS1
SCHEMBL30908785 0.86 SLC6A4 (0.49) SLC6A4HTR1DHTR1BHTR1ANOS1
SCHEMBL30909175 0.85 HTR1D (0.53) HTR1DHTR1BHTR1AHTR1F
SCHEMBL8386464 0.85 HTR1D (0.53) HTR1DHTR1BHTR1AHTR1F
SCHEMBL8720718 0.84 SLC6A4 (0.35) SLC6A4HTR1DHTR1BHTR1ANOS1
SCHEMBL8385391 0.83 SLC6A4 (0.52) SLC6A4HTR1DHTR1BHTR1AMTNR1A
SCHEMBL8386446 0.82 SLC6A4 (0.48) SLC6A4HTR1DHTR1BMTNR1AMTNR1B
SCHEMBL30908768 0.82 SLC6A4 (0.44) SLC6A4HTR1DHTR1BHTR1AHTR1F
SCHEMBL8383651 0.82 SLC6A4 (0.44) SLC6A4HTR1DHTR1BHTR1AHTR1F

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260125645-A1 METHODS AND PHARMACOLOGICAL AGENTS FOR INCREASING EXPANSION, ENGRAFTMENT OR IMMUNE OUTPUT OF HUMAN HEMATOPOIETIC STEM CELLS IN TRANSPLANTATION AND DISEASE SETTINGS VALORISATION HSJ LP (CA) 2026-05-07 US disclosed
US-5874427-A MIGRAINE ELI LILLY AND COMPANY (US) 1999-02-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260125645-A1 METHODS AND PHARMACOLOGICAL AGENTS FOR INCREASING EXPANSION, ENGRAFTMENT OR IMMUNE OUTPUT OF HUMAN HEMATOPOIETIC STEM CELLS IN TRANSPLANTATION AND DISEASE SETTINGS HTR1F, HTR1A, HTR1D SLC6A4 299/4885HTR1D 3/4885HTR1B 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.