Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 10/20 | 0.67 |
| ▸ | ACE | P12821 | 2/20 | 0.58 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.57 |
| ▸ | IL1RN | P18510 | 3/20 | 0.53 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6413187 | 0.93 | ECE1 (0.56) | ECE1 | |
| SCHEMBL7383963 | 0.93 | ECE1 (0.56) | ECE1 | |
| SCHEMBL7432650 | 0.93 | ECE1 (0.56) | ECE1 | |
| SCHEMBL6950472 | 0.87 | MAPT (0.52) | ECE1ERAP2ERAP1 | |
| SCHEMBL8387108 | 0.84 | MME (0.58) | ACE | |
| SCHEMBL7384525 | 0.84 | MME (0.58) | ACE | |
| SCHEMBL6953525 | 0.83 | MME (0.57) | ACE | |
| SCHEMBL8387205 | 0.83 | ECE1 (0.70) | ECE1ACEERAP2IL1RNERAP1 | |
| SCHEMBL7284438 | 0.82 | MMP9 (0.60) | ECE1ERAP2 | |
| SCHEMBL7284453 | 0.82 | MMP9 (0.60) | ECE1ERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784629-B1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEASES | DARWIN DISCOVERY LTD (GB) | 1999-04-28 | — | — | EP | claimed |