Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ECE1 | P42892 | 2/20 | 0.51 |
| ▸ | NMBR | P28336 | 4/20 | 0.49 |
| ▸ | TACR1 | P25103 | 1/20 | 0.49 |
| ▸ | TACR3 | P29371 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951435 | 0.90 | MEN1 (0.58) | MAPTTDP1MEN1KMT2ANPC1 | |
| SCHEMBL6946893 | 0.90 | MEN1 (0.50) | MAPTNMBRTACR1MEN1KMT2A | |
| SCHEMBL6947006 | 0.89 | MAPT (0.48) | MAPTTDP1NMBRTACR1TACR3 | |
| SCHEMBL8387115 | 0.87 | ECE1 (0.67) | ECE1ERAP2ERAP1 | |
| SCHEMBL7432650 | 0.86 | ECE1 (0.56) | ECE1MMP2MMP8MMP1MMP9 | |
| SCHEMBL7383963 | 0.86 | ECE1 (0.56) | ECE1MMP2MMP8MMP1MMP9 | |
| SCHEMBL6413187 | 0.86 | ECE1 (0.56) | ECE1MMP2MMP8MMP1MMP9 | |
| SCHEMBL6956557 | 0.84 | MMP9 (0.58) | RAB9AMMP2MMP8MMP1ANPEP | |
| SCHEMBL6946905 | 0.80 | HSD17B10 (0.45) | MEN1KMT2AALDH1A1KDM4ECYP3A4 | |
| SCHEMBL6953223 | 0.80 | MMP3 (0.63) | GAAALDH1A1MMP2MMP8MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824544-B1 | PEPTIDYL COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-04-16 | — | — | EP | claimed |
| EP-0824544-B1 | PEPTIDYL COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-04-16 | — | — | EP | disclosed |
| US-5994293-A | Peptidyl compounds and their therapeutic use | DARWIN DISCOVERY LTD. (GB) | 1999-11-30 | — | — | US | disclosed |