Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 5/20 | 0.70 |
| ▸ | ERAP2 | Q6P179 | 6/20 | 0.62 |
| ▸ | ACE | P12821 | 2/20 | 0.61 |
| ▸ | IL1RN | P18510 | 5/20 | 0.57 |
| ▸ | ERAP1 | Q9NZ08 | 4/20 | 0.57 |
| ▸ | MMP1 | P03956 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7382131 | 0.92 | MMP1 (0.67) | ECE1MMP1 | |
| SCHEMBL8764276 | 0.92 | MMP1 (0.67) | ECE1MMP1 | |
| SCHEMBL6414569 | 0.92 | MMP1 (0.67) | ECE1MMP1 | |
| SCHEMBL8390442 | 0.89 | ERAP2 (0.59) | ECE1ERAP2ACEIL1RNERAP1 | |
| SCHEMBL7894286 | 0.86 | MMP2 (0.66) | ECE1ERAP2ACEIL1RNERAP1 | |
| SCHEMBL8764745 | 0.84 | ECE1 (0.57) | ECE1ERAP2ACEIL1RNERAP1 | |
| SCHEMBL8385738 | 0.84 | MME (0.61) | ACEMMP1 | |
| SCHEMBL7382939 | 0.84 | MME (0.61) | ACEMMP1 | |
| SCHEMBL8387115 | 0.83 | ECE1 (0.67) | ECE1ERAP2ACEIL1RNERAP1 | |
| SCHEMBL7895827 | 0.81 | MMP1 (0.66) | ERAP2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784629-B1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEASES | DARWIN DISCOVERY LTD (GB) | 1999-04-28 | — | — | EP | claimed |