Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8591959 | 0.83 | ALDH1A1 (0.48) | KMT2ANR1H4ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8385239 | 0.80 | CYP1A2 (0.41) | NR1H4ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8384652 | 0.74 | FFAR1 (0.39) | NR1H4POLBRAB9A | |
| SCHEMBL1173659 | 0.74 | KDM4E (0.45) | ALDH1A1PTPN11RAB9A | |
| SCHEMBL12869586 | 0.74 | KDM4E (0.45) | ALDH1A1PTPN11RAB9A | |
| SCHEMBL21630195 | 0.73 | KDM4E (0.44) | KMT2AALDH1A1POLBMAPTRAB9A | |
| SCHEMBL1250767 | 0.72 | KDM4E (0.43) | KMT2AALDH1A1CYP2C9MAPTRAB9A | |
| SCHEMBL7532781 | 0.71 | ALDH1A1 (0.49) | KMT2AALDH1A1CYP2C9MAPTRAB9A | |
| SCHEMBL1330363 | 0.70 | SMPD1 (0.60) | KMT2ANR1H4ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8386235 | 0.69 | SLC16A3 (0.44) | KMT2AALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932743-A | Methods for the solid phase synthesis of substituted indole compounds | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-03 | — | — | US | disclosed |
| WO-1999009007-A1 | SOLID PHASE SYNTHESIS OF 2,3-DISUBSTITUTED INDOLE COMPOUNDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-02-25 | — | — | WO | disclosed |