Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 4/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 4/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.41 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.33 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.33 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31688784 | 0.91 | EPHX1 (0.42) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL4171328 | 0.90 | EPHX1 (0.49) | KDM5APHF8KDM2AKDM4CEPHX1 | |
| SCHEMBL7719751 | 0.87 | LMNA (0.44) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL10389346 | 0.86 | EPHX1 (0.46) | KDM5APHF8KDM2AKDM4CEPHX1 | |
| SCHEMBL524625 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL30478821 | 0.76 | TDP1 (0.44) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL6877330 | 0.75 | KDM5A (0.47) | KDM5APHF8KDM2AKDM4CEPHX1 | |
| SCHEMBL24556959 | 0.75 | KDM5A (0.55) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL24556984 | 0.75 | KDM5A (0.55) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL24602547 | 0.75 | KDM5A (0.55) | KDM5APHF8KDM2AKDM4CKDM7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1053893-C | Process for the manufacture of dicarboxamides | HOFFMANN LA ROCHE (CH) | 2000-06-28 | — | — | CN | disclosed |
| US-5856505-A | Intermediates for the manufacture of dicarboxamides having thrombin inhibiting activity | HOFFMANN-LA ROCHE INC. (US) | 1999-01-05 | — | — | US | disclosed |
| US-5536867-A | Process for the manufacture of dicarboxamides | HOFFMANN-LA ROCHE INC. (US) | 1996-07-16 | — | — | US | disclosed |
| CN-1117488-A | Process for the manufacture of dicarboxamides | HOFFMANN LA ROCHE (CH) | 1996-02-28 | — | — | CN | disclosed |
| EP-0684238-A2 | Process for the manufacture of dicarboxamides | F. HOFFMANN-LA ROCHE AG (CH) | 1995-11-29 | — | — | EP | disclosed |