Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 3/20 | 0.47 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.47 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.40 |
| ▸ | F2R | P25116 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1677750 | 0.98 | KDM5A (0.46) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL10389346 | 0.87 | EPHX1 (0.46) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL4171328 | 0.86 | EPHX1 (0.49) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL3197213 | 0.84 | ITGB3 (0.48) | KDM5APHF8KDM2AKDM4CKDM4A | |
| Hydrochloric Acid SCHEMBL1677522 | 0.81 | EPHX1 (0.45) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL716430 | 0.81 | SIGMAR1 (0.48) | EPHX1HPGDKMT2A | |
| SCHEMBL7716618 | 0.80 | PLG (0.44) | KDM5APHF8KDM2AKDM4CLMNA | |
| SCHEMBL27617747 | 0.80 | EPHX2 (0.51) | EPHX1HPGDALDH1A1EPHX2KMT2A | |
| SCHEMBL31688784 | 0.80 | EPHX1 (0.42) | KDM5APHF8KDM2AKDM4CKDM4A | |
| SCHEMBL1595661 | 0.79 | HPGD (0.55) | KDM5APHF8KDM2AKDM4CKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100522150-C | Angiogenesis inhibitor | SANTEN PHARMACEUTICAL CO LTD (JP) | 2009-08-05 | — | — | CN | disclosed |
| CN-1324012-C | TNF-alpha prodn. inhibitors | SANTEN PHARMACEUTICAL CO LTD (JP) | 2007-07-04 | — | — | CN | disclosed |
| CN-1307159-C | TNF-alpha prodn. inhibitors | SANTEN PHARMACEUTICAL CO LTD (JP) | 2007-03-28 | — | — | CN | disclosed |
| CN-1284771-C | TNF-alpha production inhibitors | SANTEN PHARMACEUTICAL CO LTD (JP) | 2006-11-15 | — | — | CN | disclosed |
| CN-1604774-A | Angiogenesis inhibitor | SANTEN PHARMACEUTICAL CO LTD (JP) | 2005-04-06 | — | — | CN | disclosed |
| CN-1590375-A | TNF-alpha prodn. inhibitors | SANTEN PHARMACEUTICAL CO LTD (JP) | 2005-03-09 | — | — | CN | disclosed |
| CN-1590374-A | TNF-alpha prodn. inhibitors | SANTEN PHARMACEUTICAL CO LTD (JP) | 2005-03-09 | — | — | CN | disclosed |
| EP-1457205-A1 | ANGIOGENESIS INHIBITOR | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-09-15 | — | — | EP | disclosed |
| CN-1432000-A | TNF-alpha production inhibitors | SANTEN PHARMACEUTICAL CO LTD (JP) | 2003-07-23 | — | — | CN | disclosed |