Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 4/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.46 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.42 |
| ▸ | BRAF | P15056 | 4/20 | 0.40 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13139153 | 0.79 | BRAF (0.44) | MAP3K20BRAFCYP3A4CYP2C9 | |
| SCHEMBL10293139 | 0.79 | BRAF (0.40) | SLC40A1MAP3K20BRAFCYP3A4 | |
| SCHEMBL12960827 | 0.77 | BRAF (0.39) | SLC40A1MAP3K20BRAFCYP3A4 | |
| SCHEMBL855957 | 0.75 | KEAP1 (0.48) | SLC40A1GLO1MAP3K20NFE2L2KEAP1 | |
| SCHEMBL12960655 | 0.75 | BRAF (0.42) | BRAF | |
| SCHEMBL855853 | 0.70 | SLC40A1 (0.45) | SLC40A1GLO1MAP3K20NFE2L2KEAP1 | |
| SCHEMBL12340780 | 0.70 | BRAF (0.41) | MAP3K20BRAFCYP3A4CYP2C9 | |
| SCHEMBL13138465 | 0.69 | ALDH1A1 (0.47) | GAACYP3A4CYP2C9 | |
| SCHEMBL13138311 | 0.69 | SLC40A1 (0.47) | SLC40A1GLO1BRAFCYP3A4CYP2C9 | |
| SCHEMBL297187 | 0.68 | CYP3A4 (0.66) | MAP3K20NFE2L2KEAP1BRAFCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249118-A1 | protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents | PLEXXIKON INC. | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249118-A1 | protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents | MAP4K1, MAP4K2, MAP3K1 | SLC40A1 4735/4885GLO1 2658/4885MAP3K20 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.