Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8390149 | 0.87 | INSR (0.57) | INSRALDH1A1HPGDKDM4EPKM | |
| SCHEMBL8388983 | 0.82 | INSR (0.77) | INSRALDH1A1HPGDKDM4EPKM | |
| SCHEMBL4613852 | 0.72 | ALDH1A1 (0.61) | ALDH1A1HPGDKDM4EPKMSMN1; SMN2 | |
| SCHEMBL5452731 | 0.71 | ALDH1A1 (0.43) | INSRALDH1A1HPGDKDM4EPKM | |
| SCHEMBL5452728 | 0.71 | ALDH1A1 (0.43) | INSRALDH1A1HPGDKDM4EPKM | |
| SCHEMBL14938756 | 0.70 | INSR (0.44) | INSRALDH1A1HPGDKDM4EPKM | |
| SCHEMBL9032592 | 0.69 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4EPKMSMN1; SMN2 | |
| SCHEMBL8388977 | 0.69 | INSR (0.84) | INSRALDH1A1KDM4EPKMMAPT | |
| SCHEMBL14938732 | 0.69 | INSR (0.60) | INSRALDH1A1HPGDKDM4EPKM | |
| SCHEMBL6624917 | 0.68 | MAPT (0.54) | ALDH1A1HPGDKDM4EPKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001331-A | INTRODUCING INTO PATIENT BENZYLTHIAZOL-3-IUM DERIVATIVES OF GIVEN FORMULA; ALLOWING TIME FOR COMPOUND TO ASSOCIATE WITH AMYLOID; DETECTING THE LABELED COMPOUND ASSOCIATED WITH AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 1999-12-14 | — | — | US | claimed |
| WO-1997026919-A2 | METHOD OF IMAGING AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 1997-07-31 | — | — | WO | claimed |
| US-6001331-A | INTRODUCING INTO PATIENT BENZYLTHIAZOL-3-IUM DERIVATIVES OF GIVEN FORMULA; ALLOWING TIME FOR COMPOUND TO ASSOCIATE WITH AMYLOID; DETECTING THE LABELED COMPOUND ASSOCIATED WITH AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 1999-12-14 | — | — | US | disclosed |