Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8337233 | 0.91 | SMN1; SMN2 (0.32) | CA1CA2ACHEPTGS2HIF1A | |
| SCHEMBL8336357 | 0.90 | HIF1A (0.34) | ALDH1A1HIF1A | |
| SCHEMBL8333752 | 0.90 | HIF1A (0.34) | ALDH1A1HIF1A | |
| SCHEMBL8335857 | 0.89 | GAA (0.31) | GAAALDH1A1PTGS2HIF1AAKR1C3 | |
| SCHEMBL8389248 | 0.88 | TAS1R3 (0.32) | ALDH1A1HIF1A | |
| SCHEMBL8339742 | 0.87 | BCHE (0.30) | ACHE | |
| SCHEMBL8334767 | 0.86 | ALDH1A1 (0.33) | GAAALDH1A1CA1CA2HIF1A | |
| SCHEMBL8338614 | 0.86 | SMN1; SMN2 (0.35) | GAAALDH1A1HIF1A | |
| SCHEMBL8340685 | 0.86 | SMN1; SMN2 (0.33) | ALDH1A1HIF1A | |
| SCHEMBL8338441 | 0.85 | SMN1; SMN2 (0.34) | GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |