SCHEMBL83906

SCHEMBL83906

O=C(O)c1ccc2c(c1C(=O)O)Cc1ccccc1O2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.48
MAOB P27338 1/20 0.48
CYP2C9 P11712 1/20 0.41
ACSL1 P33121 1/20 0.40
ALOX5 P09917 3/20 0.38
TRPA1 O75762 1/20 0.38
GSR P00390 1/20 0.37
MAPKAPK2 P49137 1/20 0.37
ALDH1A1 P00352 3/20 0.35
ALOX15 P16050 1/20 0.35
KDM4E B2RXH2 3/20 0.35
HPGD P15428 2/20 0.35
GAA P10253 1/20 0.35
MAPK1 P28482 1/20 0.35
NOTUM Q6P988 1/20 0.35
HSD17B10 Q99714 1/20 0.35
MEN1 O00255 2/20 0.34
POLB P06746 2/20 0.34
PKM P14618 2/20 0.34
KMT2A Q03164 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6695264 0.90 MAOA (0.44) MAOAMAOBCYP2C9ACSL1ALOX5
SCHEMBL9151406 0.89 MAOA (0.41) MAOAMAOBCYP2C9ACSL1ALOX5
SCHEMBL8198726 0.84 MAOA (0.52) MAOAMAOBCYP2C9ACSL1ALOX5
SCHEMBL5692 0.84 MAOA (0.52) MAOAMAOBCYP2C9ACSL1ALOX5
SCHEMBL1672256 0.83 MAOA (0.47) MAOAMAOBACSL1ALOX5GSR
SCHEMBL4298022 0.83 MAOA (0.47) MAOAMAOBACSL1ALOX5GSR
Hydrochloric Acid SCHEMBL6864147 0.83 MAOA (0.50) MAOAMAOBCYP2C9ACSL1ALOX5
Ammonia Solution, Strong SCHEMBL7709867 0.83 MAOA (0.50) MAOAMAOBCYP2C9ACSL1ALOX5
SCHEMBL11506362 0.82 MAOA (0.46) MAOAMAOBACSL1ALOX5GSR
SCHEMBL2313646 0.82 MAOA (0.46) MAOAMAOBACSL1ALOX5GSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150322200-A1 AMORPHOUS POLYESTER COMPOSITIONS SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-11-12 US claimed
WO-2015171709-A1 AMORPHOUS POLYESTER COMPOSITIONS SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-11-12 WO claimed
EP-0675145-B1 Xanthene polymers and copolymers GEN ELECTRIC (US) 1998-11-18 EP claimed
US-5504184-A Xanthene polymers, and copolymers, and method for making GENERAL ELECTRIC COMPANY (US) 1996-04-02 US claimed
US-5466777-A Xanthene polymers, and copolymers, and method for making GENERAL ELECTRIC COMPANY (US) 1995-11-14 US claimed
EP-0675145-A2 Xanthene polymers and copolymers GENERAL ELECTRIC COMPANY (US) 1995-10-04 EP claimed
JP-8041183-A None JP disclosed
US-20160159940-A1 POLYDENDRONS The Univeristy of Liverpool (GB) 2016-06-09 US disclosed
US-20160159954-A1 POLYDENDRONS The Univeristy of Liverpool (GB) 2016-06-09 US disclosed
WO-2015171709-A1 AMORPHOUS POLYESTER COMPOSITIONS SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-11-12 WO disclosed
US-20150322200-A1 AMORPHOUS POLYESTER COMPOSITIONS SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-11-12 US disclosed
US-20150322200-A1 AMORPHOUS POLYESTER COMPOSITIONS SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-11-12 US disclosed
WO-2015171709-A1 AMORPHOUS POLYESTER COMPOSITIONS SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2015-11-12 WO disclosed
JP-H0841183-A XANTHENE POLYMER AND XANTHENE COPOLYMER, AND THEIR PREPARATION GENERAL ELECTRIC CO <GE> 1996-02-13 JP disclosed
US-5466777-A Xanthene polymers, and copolymers, and method for making GENERAL ELECTRIC COMPANY (US) 1995-11-14 US disclosed
EP-0675145-A2 Xanthene polymers and copolymers GENERAL ELECTRIC COMPANY (US) 1995-10-04 EP disclosed
US-5430199-A Method for recovering phenol and xanthene values from bisphenol A tars GENERAL ELECTRIC COMPANY (US) 1995-07-04 US disclosed
WO-1995016210-A1 A METHOD AND MATERIAL FOR THE DETECTION OF IONISING RADIATION BRITISH NUCLEAR FUELS PLC (GB) 1995-06-15 WO disclosed
US-3957989-A ADMINISTERING RICHARDSON-MERRELL INC. (US) 1976-05-18 US disclosed
US-3957986-A Antiviral compositions containing bis-basic esters and amides of xanthene and xanthone RICHARDSON-MERRELL INC. (US) 1976-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160159954-A1 POLYDENDRONS PARN, DSTN, DAD1 MAOA 2763/4885MAOB 2988/4885CYP2C9 3468/4885
US-20160159940-A1 POLYDENDRONS PARN, DSTN, DBN1 MAOA 2246/4885MAOB 2527/4885CYP2C9 2920/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.