SCHEMBL4298022

SCHEMBL4298022

O=C(O)c1c(Cl)ccc2c1Cc1ccccc1O2

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.47
MAOB P27338 1/20 0.47
ACSL1 P33121 1/20 0.40
DPP4 P27487 1/20 0.40
GSR P00390 1/20 0.36
MAPKAPK2 P49137 1/20 0.36
ALDH1A1 P00352 3/20 0.36
KDM4E B2RXH2 3/20 0.36
HSD17B10 Q99714 2/20 0.36
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
MAPT P10636 1/20 0.35
ALOX15 P16050 1/20 0.35
CYP2C19 P33261 1/20 0.35
THPO P40225 1/20 0.35
PMP22 Q01453 1/20 0.35
ALOX5 P09917 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL83906 0.83 MAOA (0.48) MAOAMAOBACSL1GSRMAPKAPK2
SCHEMBL17179947 0.83 HSP90AA1 (0.40) MAOAMAOBACSL1GSRMAPKAPK2
SCHEMBL1672256 0.82 MAOA (0.47) MAOAMAOBACSL1GSRMAPKAPK2
SCHEMBL11506362 0.81 MAOA (0.46) MAOAMAOBACSL1GSRMAPKAPK2
SCHEMBL2313646 0.81 MAOA (0.46) MAOAMAOBACSL1GSRMAPKAPK2
Potassium SCHEMBL4602990 0.79 MAOA (0.44) MAOAMAOBACSL1GSRMAPKAPK2
SCHEMBL16563060 0.79 MAOA (0.44) MAOAMAOBACSL1GSRMAPKAPK2
SCHEMBL3071991 0.79 MAPKAPK2 (0.46) MAOAMAOBACSL1GSRMAPKAPK2
SCHEMBL9124376 0.79 MAOA (0.55) MAOAMAOBACSL1MAPKAPK2GAA
SCHEMBL4742293 0.78 ALOX5 (0.55) MAOAMAOBACSL1ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090011963-A1 TRUCK FLEET FUEL ECONOMY BY THE USE OF OPTIMIZED ENGINE OIL, TRANSMISSION FLUID, AND GEAR OIL AFTON CHEMICAL CORPORATION 2009-01-08 US disclosed
US-5703023-A VINYLAROMATIC-MALEIC ESTER POLYMERIC VISCOSITY INDEX IMPROVER ETHYL CORPORATION (US) 1997-12-30 US disclosed
US-5652201-A INCLUDING OIL-SOLUBLE OVERBASED ALKALINE EARTH METAL-CONTAINING SULFONATE DETERGENT, BORON-FREE ADDITIVE FORMED BY HEATING ASHLESS DISPERSANT CONTAINING BASIC NITROGEN AND/OR HYDROXYL GROUP WITH INORGANIC PHOSPHORUS ACID ETHYL PETROLEUM ADDITIVES INC. (US) 1997-07-29 US disclosed
US-5498355-A CRANKCASE OIL DISPERSANT, A FIRST SUCCINYLATED POLYALKYLENE REACTED WITH AN ALKYLENE POLYAMINE AND A SECOND REACTED WITH A HYDROXYPROPYLATED ALKYLENE POLYAMINE ETHYL CORPORATION (US) 1996-03-12 US disclosed
EP-0516461-B1 Lubricating oil compositions and concentrates and the use thereof ETHYL PETROLEUM ADDITIVES INC (US) 1996-02-28 EP disclosed
EP-0492934-B1 Lubricating oil compositions and concentrates and the use thereof ETHYL PETROLEUM ADDITIVES INC (US) 1994-08-10 EP disclosed
EP-0516461-A1 Lubricating oil compositions and concentrates and the use thereof ETHYL PETROLEUM ADDITIVES, INC. (US) 1992-12-02 EP disclosed
EP-0493928-A1 Lubricating oil compositions, concentrates and the use thereof ETHYL PETROLEUM ADDITIVES, INC. (US) 1992-07-08 EP disclosed
EP-0492934-A1 Lubricating oil compositions and concentrates and the use thereof ETHYL PETROLEUM ADDITIVES, INC. (US) 1992-07-01 EP disclosed
US-4162985-A HYDROGENATED VINYLARENE-CONJUGATED DIENE POLYMER, EXTREME PRESSURE COMPONENT, OIL BASE THE LUBRIZOL CORPORATION (US) 1979-07-31 US disclosed