Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NEU3 | Q9UQ49 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8397214 | 0.99 | SIGMAR1 (0.50) | SIGMAR1KMT2ASMN1; SMN2MEN1PKM | |
| SCHEMBL8392264 | 0.88 | SIGMAR1 (0.48) | SIGMAR1KMT2ASMN1; SMN2MEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8397186 | 0.87 | SIGMAR1 (0.47) | SIGMAR1KMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8392676 | 0.80 | ALDH1A1 (0.43) | SIGMAR1SMN1; SMN2PKMMAPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8392007 | 0.79 | ALDH1A1 (0.43) | SIGMAR1SMN1; SMN2PKMMAPK1ALDH1A1 | |
| SCHEMBL8394240 | 0.74 | MEN1 (0.48) | KMT2ASMN1; SMN2MEN1ALDH1A1KDM4E | |
| SCHEMBL8392827 | 0.73 | MAPT (0.60) | KMT2ASMN1; SMN2MEN1ALDH1A1HSD17B10 | |
| SCHEMBL8393004 | 0.72 | SIGMAR1 (0.62) | SIGMAR1KMT2AMEN1HPGDKDM4E | |
| Hydrochloric Acid SCHEMBL8396117 | 0.72 | MAPT (0.58) | KMT2ASMN1; SMN2MEN1ALDH1A1HSD17B10 | |
| SCHEMBL8392013 | 0.72 | SMN1; SMN2 (0.47) | KMT2ASMN1; SMN2MEN1PKMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690851-B1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AB (SE) | 1999-05-19 | — | — | EP | claimed |
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | claimed |
| EP-0690851-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | Astra Aktiebolag (SE) | 1996-01-10 | — | — | EP | claimed |
| WO-1994021621-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AKTIEBOLAG (SE) | 1994-09-29 | — | — | WO | claimed |