Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 7/20 | 0.43 |
| ▸ | MMP1 | P03956 | 6/20 | 0.43 |
| ▸ | MMP13 | P45452 | 5/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 3/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8336310 | 1.00 | MMP9 (0.43) | MMP9MMP1MMP13ADAM17POLB | |
| SCHEMBL8334670 | 0.99 | MMP9 (0.41) | MMP9MMP1MMP13ADAM17POLB | |
| SCHEMBL8338140 | 0.96 | MMP9 (0.38) | MMP9MMP1MMP13ADAM17POLB | |
| SCHEMBL8338207 | 0.92 | TDP1 (0.37) | MMP9MMP1MMP13ADAM17KDM4E | |
| SCHEMBL8339955 | 0.91 | POLB (0.39) | MMP9MMP1MMP13ADAM17POLB | |
| SCHEMBL8332853 | 0.91 | MMP9 (0.41) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL8336849 | 0.90 | MMP9 (0.44) | MMP9MMP1MMP13ADAM17POLB | |
| SCHEMBL8340743 | 0.90 | MMP9 (0.40) | MMP9MMP1MMP13ADAM17MMP2 | |
| SCHEMBL8337089 | 0.89 | MMP9 (0.43) | MMP9MMP1MMP13ADAM17POLB | |
| SCHEMBL8341296 | 0.89 | TDP1 (0.40) | KDM4ECRHBPHTTCRHR2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |