Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 5/20 | 0.41 |
| ▸ | MMP13 | P45452 | 5/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.41 |
| ▸ | MMP1 | P03956 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8334670 | 0.91 | MMP9 (0.41) | MMP9MMP13ADAM17MMP1KDM4E | |
| SCHEMBL8336310 | 0.91 | MMP9 (0.43) | MMP9MMP13ADAM17MMP1KDM4E | |
| SCHEMBL8392500 | 0.91 | MMP9 (0.43) | MMP9MMP13ADAM17MMP1KDM4E | |
| SCHEMBL8339304 | 0.90 | MMP9 (0.42) | MMP9MMP13ADAM17MMP1KDM4E | |
| SCHEMBL8340743 | 0.90 | MMP9 (0.40) | MMP9MMP13ADAM17MMP1KMT2A | |
| SCHEMBL8338841 | 0.89 | MMP9 (0.40) | MMP9MMP13ADAM17MMP1KDM4E | |
| SCHEMBL8338140 | 0.89 | MMP9 (0.38) | MMP9MMP13ADAM17MMP1KMT2A | |
| SCHEMBL8341075 | 0.88 | NPC1 (0.39) | MMP9MMP13ADAM17MMP1KMT2A | |
| SCHEMBL8340696 | 0.86 | RAB9A (0.46) | KMT2AKDM4EHTTCNR1CNR2 | |
| SCHEMBL8337089 | 0.85 | MMP9 (0.43) | MMP9MMP13ADAM17MMP1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |