Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 5/20 | 0.34 |
| ▸ | MMP13 | P45452 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.33 |
| ▸ | MMP1 | P03956 | 4/20 | 0.33 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8334670 | 0.91 | MMP9 (0.41) | POLBMMP9MMP13ADAM17MMP1 | |
| SCHEMBL8336310 | 0.91 | MMP9 (0.43) | POLBMMP9MMP13ADAM17MMP1 | |
| SCHEMBL8392500 | 0.91 | MMP9 (0.43) | POLBMMP9MMP13ADAM17MMP1 | |
| SCHEMBL8340160 | 0.90 | MAPT (0.37) | POLBLMNAALDH1A1MAPTALOX12 | |
| SCHEMBL8334100 | 0.90 | POLB (0.41) | POLBMMP9MMP13LMNAMMP8 | |
| SCHEMBL8338140 | 0.89 | MMP9 (0.38) | POLBMMP9MMP13ALDH1A1MAPT | |
| SCHEMBL8335548 | 0.88 | KDM4E (0.35) | POLBLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8340341 | 0.85 | KDM4E (0.36) | LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8338207 | 0.84 | TDP1 (0.37) | MMP9MMP13LMNAALDH1A1MAPT | |
| SCHEMBL8332853 | 0.83 | MMP9 (0.41) | MMP9MMP13ADAM17MMP1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |