Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.79 |
| ▸ | CPA1 | P15085 | 7/20 | 0.68 |
| ▸ | CPA3 | P15088 | 3/20 | 0.68 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.68 |
| ▸ | CPB1 | P15086 | 1/20 | 0.68 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.68 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.61 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.61 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.61 |
| ▸ | MME | P08473 | 1/20 | 0.58 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.56 |
| ▸ | ALPI | P09923 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | XIAP | P98170 | 1/20 | 0.55 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL839261 | 1.00 | CYP1A2 (0.79) | CYP1A2CPA1CPA3FOLH1CPB1 | |
| SCHEMBL6154166 | 1.00 | CYP1A2 (0.79) | CYP1A2CPA1CPA3FOLH1CPB1 | |
| SCHEMBL8106525 | 1.00 | CYP1A2 (0.79) | CYP1A2CPA1CPA3FOLH1CPB1 | |
| Ammonia Solution, Strong SCHEMBL7515476 | 0.98 | CYP1A2 (0.76) | CYP1A2CPA1CPA3FOLH1CPB1 | |
| SCHEMBL6542093 | 0.89 | CYP1A2 (0.76) | CYP1A2CPA1CPA3FOLH1CPB1 | |
| SCHEMBL4664822 | 0.89 | CYP1A2 (1.00) | CYP1A2CPA1CPA3FOLH1CPB1 | |
| SCHEMBL9622038 | 0.86 | CYP1A2 (0.86) | CYP1A2CPA1CPA3FOLH1CPB1 | |
| SCHEMBL7439697 | 0.86 | CYP1A2 (0.86) | CYP1A2CPA1CPA3FOLH1CPB1 | |
| SCHEMBL22115491 | 0.86 | CYP1A2 (0.95) | CYP1A2CPA1CPA3FOLH1CPB1 | |
| SCHEMBL7432418 | 0.86 | CYP1A2 (0.86) | CYP1A2CPA1CPA3FOLH1CPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10093625-B2 | Process for the preparation of [[2(S)-[[4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]amino]acetic acid dihydrate | MSN LABORATORIES PRIVATE LIMITED (IN) | 2018-10-09 | — | — | US | claimed |
| US-20170247328-A1 | IMPROVED PROCESS FOR THE PREPARATION OF [[2(S)-[[4(R)-(3-HYDROXYPHENYL)-3(R),4-DIMETHYL-1-PIPERIDINYL]METHYL]-1-OXO-3-PHENYLPROPYL]AMINO]ACETIC ACID DIHYDRATE | MSN LABORATORIES PRIVATE LIMITED (IN) | 2017-08-31 | — | — | US | claimed |
| EP-2238107-A1 | PROCESS FOR THE MANUFACTURE OF A 6-FLUORO-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE DERIVATIVE | Boehringer Ingelheim International GmbH (DE) | 2010-10-13 | — | — | EP | claimed |
| CN-100546969-C | Split the method for 2-methylol-3-phenylpropionic acid optical isomer | SHANGHAI INST OF MEDICINE INDU (CN) | 2009-10-07 | — | — | CN | claimed |
| WO-2009092580-A1 | PROCESS FOR THE MANUFACTURE OF A 6-FLUORO-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE DERIVATIVE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-07-30 | — | — | WO | claimed |
| CN-1931821-A | Process of resolving optical isomer of 2-hydroxmethyl-3-phenylpropionic acid | SHANGHAI INST OF MEDICINE INDU (CN) | 2007-03-21 | — | — | CN | claimed |
| US-20060089503-A1 | Processes for producing optically active 2-thiomethyl-3-phenylpropionic acid derivative and for producing intermediate therefor | KANEKA CORPORATION (JP) | 2006-04-27 | — | — | US | claimed |
| EP-1577310-A1 | PROCESSES FOR PRODUCING OPTICALLY ACTIVE 2-THIOMETHYL-3-PHENYLPROPIONIC ACID DERIVATIVE AND FOR PRODUCING INTERMEDIATE THEREFOR | KANEKA CORPORATION (JP) | 2005-09-21 | — | — | EP | claimed |
| EP-0937710-B1 | Method for producing an optically active phenylpropionic acid derivative | AJINOMOTO KK (JP) | 2003-04-16 | — | — | EP | claimed |
| EP-0906900-B1 | A process for preparing optically active 2-hydroxy-methyl-3-phenylpropionic acid | AJINOMOTO KK (JP) | 2002-01-23 | — | — | EP | claimed |
| US-20010014754-A1 | Method for producing optically active phenylpropionic acid derivative | AJINOMOTO CO., INC. (JP) | 2001-08-16 | — | — | US | claimed |
| US-6093846-A | BY REACTING WITH SPECIFIED OPTICALLY ACTIVE AMINES SUCH AS CIS-1-AMINO-2-INDANOL IN A SOLVENT, PRODUCING TWO DIASTEREOISOMERIC SALTS OF DIFFERING SOLUBILITY, FRACTIONAL CRYSTALLIZATION AND DECOMPOSING THE SALT WITH ALKALI OR ACID | AJINOMOTO CO., INC. (JP) | 2000-07-25 | — | — | US | claimed |
| US-6031121-A | Method for producing optically active phenylpropionic acid derivative | AJINOMOTO CO., INC. (JP) | 2000-02-29 | — | — | US | claimed |
| US-6028217-A | CHEMICAL INTERMEDIATE FOR RENIN INHIBITOR OR ENKEPHALINASE ENZYME INHIBITOR | AJINOMOTO CO., INC. (JP) | 2000-02-22 | — | — | US | claimed |
| EP-0937710-A1 | Method for producing an optically active phenylpropionic acid derivative | Ajinomoto Co., Inc. (JP) | 1999-08-25 | — | — | EP | claimed |
| EP-0906900-A1 | A process for preparing optically active 2-hydroxy-methyl-3-phenylpropionic acid | Ajinomoto Co., Inc. (JP) | 1999-04-07 | — | — | EP | claimed |
| US-4731126-A | HYDROXYMETHYL CARBOXYLIC ACID | THE DOW CHEMICAL COMPANY (US) | 1988-03-15 | — | — | US | claimed |
| JP-11106363-A | — | — | None | — | — | JP | disclosed |
| US-4734367-A | OPTICALLY ACTIVE INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 1988-03-29 | — | — | US | disclosed |
| US-4731126-A | HYDROXYMETHYL CARBOXYLIC ACID | THE DOW CHEMICAL COMPANY (US) | 1988-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170247328-A1 | IMPROVED PROCESS FOR THE PREPARATION OF [[2(S)-[[4(R)-(3-HYDROXYPHENYL)-3(R),4-DIMETHYL-1-PIPERIDINYL]METHYL]-1-OXO-3-PHENYLPROPYL]AMINO]ACETIC ACID DIHYDRATE | HPD, GRHPR, HCAR2 | CYP1A2 251/4885CPA1 963/4885CPA3 1891/4885 |
| US-10093625-B2 | Process for the preparation of [[2(S)-[[4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]amino]acetic acid dihydrate | HPD, HCAR2, GRHPR | CYP1A2 225/4885CPA1 1154/4885CPA3 2028/4885 |
| US-20010014754-A1 | Method for producing optically active phenylpropionic acid derivative | ACE, DNPEP, AGT | CYP1A2 2042/4885CPA1 168/4885CPA3 199/4885 |
| US-20060089503-A1 | Processes for producing optically active 2-thiomethyl-3-phenylpropionic acid derivative and for producing intermediate therefor | NOTUM, FAR1, ALDH7A1 | CYP1A2 317/4885CPA1 1349/4885CPA3 2409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.