Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 9/20 | 0.66 |
| ▸ | NPC1 | O15118 | 8/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | GPR183 | P32249 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8393112 | 1.00 | ALDH1A1 (0.73) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3010777 | 0.84 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3010773 | 0.84 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3441762 | 0.84 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3441759 | 0.84 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8788355 | 0.81 | ALDH1A1 (0.65) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8788351 | 0.81 | ALDH1A1 (0.65) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9652216 | 0.80 | RAB9A (0.73) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9652221 | 0.80 | RAB9A (0.73) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4819739 | 0.80 | RAB9A (0.73) | ALDH1A1L3MBTL1SMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998399-A | Guanidine derivatives useful in therapy as inhibitors of nitric oxide synthetase | ASTRA AKTIEBOLAG (SE) | 1999-12-07 | — | — | US | disclosed |
| EP-0690851-B1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AB (SE) | 1999-05-19 | — | — | EP | disclosed |
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | disclosed |
| EP-0690851-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | Astra Aktiebolag (SE) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021621-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AKTIEBOLAG (SE) | 1994-09-29 | — | — | WO | disclosed |