Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3246833 | 0.90 | CALM1 (0.40) | CALM1POLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL3246733 | 0.77 | ALDH1A1 (0.45) | SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL3240221 | 0.73 | HSP90AA1 (0.41) | POLBSMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL3238260 | 0.66 | L3MBTL1 (0.45) | SMN1; SMN2MEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL579760 | 0.63 | CALM1 (0.61) | CALM1POLBSMN1; SMN2MAPTLMNA | |
| SCHEMBL30714383 | 0.63 | CALM1 (0.61) | CALM1POLBSMN1; SMN2MAPTLMNA | |
| SCHEMBL8171761 | 0.62 | CALM1 (0.65) | CALM1SMN1; SMN2KMT2ATP53MAPT | |
| SCHEMBL9183532 | 0.62 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2ATP53MAPT | |
| SCHEMBL5873476 | 0.60 | CALM1 (0.67) | CALM1POLBMAPTGAAS1PR1 | |
| SCHEMBL58054 | 0.60 | CALM1 (0.58) | CALM1SMN1; SMN2MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318429-A1 | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318429-A1 | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives | CFTR, PKD1, PKD2 | CALM1 4562/4885POLB 2710/4885SMN1; SMN2 4546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.