Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8394382 | 1.00 | MTNR1A (0.69) | MTNR1ALMNAPOLBMAPTTP53 | |
| SCHEMBL8394384 | 1.00 | MTNR1A (0.69) | MTNR1ALMNAPOLBMAPTTP53 | |
| SCHEMBL16303447 | 0.80 | MTNR1A (0.58) | MTNR1ALMNAPOLBMAPTTP53 | |
| SCHEMBL16303414 | 0.78 | MTNR1A (0.57) | MTNR1ALMNAPOLBMAPTTP53 | |
| SCHEMBL9082928 | 0.78 | MTNR1A (0.57) | MTNR1ALMNAPOLBMAPTTP53 | |
| SCHEMBL11974942 | 0.77 | DRD2 (0.54) | MTNR1A | |
| Hydrochloric Acid SCHEMBL10780018 | 0.77 | MTNR1A (0.56) | MTNR1ALMNAPOLBMAPTTP53 | |
| SCHEMBL17888019 | 0.76 | MTNR1A (0.64) | MTNR1ALMNAPOLBMAPTTP53 | |
| SCHEMBL19750357 | 0.76 | MTNR1A (0.54) | MTNR1ALMNAPOLBMAPTTP53 | |
| Hydrochloric Acid SCHEMBL1026189 | 0.76 | DRD2 (0.52) | MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6008219-A | Bicyclic amine derivatives and their use as anti-psychotic agents | SMITHKLINE BEECH P.L.C. (GB) | 1999-12-28 | — | — | US | disclosed |
| WO-1996030333-A1 | BICYCLIC AMINE DERIVATIVES AND THEIR USE AS ANTI-PSYCHOTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1996-10-03 | — | — | WO | disclosed |