Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8392326 | 0.81 | SIGMAR1 (0.57) | SIGMAR1LMNAHPGDKMT2AMEN1 | |
| SCHEMBL8392887 | 0.81 | SIGMAR1 (0.60) | SIGMAR1LMNAHPGDKMT2AMEN1 | |
| SCHEMBL11485191 | 0.79 | SIGMAR1 (0.50) | SIGMAR1LMNAKMT2AMEN1HTT | |
| Hydrochloric Acid SCHEMBL11484958 | 0.77 | SIGMAR1 (0.49) | SIGMAR1LMNAHPGDKMT2AMEN1 | |
| SCHEMBL9537649 | 0.73 | POLB (0.39) | SIGMAR1KMT2AKDM4EMAPTPOLB | |
| SCHEMBL8392582 | 0.72 | HTT (0.43) | SIGMAR1LMNAKMT2AMEN1HTT | |
| SCHEMBL7509274 | 0.72 | PLAU (0.44) | POLB | |
| SCHEMBL8518311 | 0.72 | SIGMAR1 (0.54) | SIGMAR1LMNAKMT2AMEN1HTT | |
| SCHEMBL9537404 | 0.72 | SIGMAR1 (0.39) | SIGMAR1LMNAKMT2AMAPTGAA | |
| SCHEMBL8392882 | 0.71 | SIGMAR1 (0.47) | SIGMAR1LMNAKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690851-B1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AB (SE) | 1999-05-19 | — | — | EP | claimed |
| EP-0690851-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | Astra Aktiebolag (SE) | 1996-01-10 | — | — | EP | claimed |
| WO-1994021621-A1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AKTIEBOLAG (SE) | 1994-09-29 | — | — | WO | claimed |
| EP-0690851-B1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AB (SE) | 1999-05-19 | — | — | EP | disclosed |